US StockDetailed Quotes

Provided by Tiger Trade Technology Pte. Ltd.

Ionis Pharmaceuticals

54.21

-1.4400-2.59%

Post-market: 54.20-0.0100-0.02%19:52 EDT

Volume:2.18M

Turnover:119.32M

Market Cap:9.01B

PE:-15.58

High:56.16

Open:55.94

Low:54.16

Close:55.65

52wk High:86.74

52wk Low:50.01

Shares:166.18M

Float Shares:161.92M

Volume Ratio:0.49

T/O Rate:1.34%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-3.4800

EPS(LYR):-2.3812

ROE:-105.50%

ROA:-12.42%

PB:20.49

PE(LYR):-22.77

Loading ...

Overview Company News Filings

Beneficial Ownership Change

SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals

Beneficial Ownership Change

SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals

Beneficial Ownership Change

SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals

Beneficial Ownership Change

SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals

Beneficial Ownership Change

SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals

Correspondence

CORRESP [Cover] - Correspondence

Employee Stock Ownership

S-8 - Securities to be offered to employees in employee benefit plans

Major Issues Report

8-K - Current report

Major Issues Report

8-K - Current report

Quarterly Report

10-Q - Quarterly report [Sections 13 or 15(d)]

Major Issues Report

8-K - Current report

Beneficial Ownership Change

SC 13D/A [Amend] - General statement of acquisition of beneficial ownership

Major Issues Report

8-K - Current report

Beneficial Ownership Change

SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals

Correspondence

CORRESP [Cover] - Correspondence

Beneficial Ownership Change

SC 13D/A [Amend] - General statement of acquisition of beneficial ownership

Major Issues Report

8-K - Current report

Employee Stock Ownership

S-8 - Securities to be offered to employees in employee benefit plans

Quarterly Report

10-Q - Quarterly report [Sections 13 or 15(d)]

Major Issues Report

8-K - Current report

{"basename":"","ssrTDKData":{"titleTemplate":"%s - Tiger Brokers","title":"Tiger Brokers HK | Online Trading in stocks, bonds & ETFS","description":"Discover Tiger Brokers HK, an online trading platform for stocks&ETFs, options&futures, bonds and crypto. Open an account to enjoy low commission trading today!","keywords":"tiger trading,tiger security,tiger broker hk,tigers co ltd,tiger trade hk,tiger brokers hk,stock broker,securities broker,online brokerage,hong kong broker,hk broker,online stock trading,online trading platform,stock trading platforms,trading application,stock trading,stock trading hong kong,buying stocks in hong kong,tiger brokers","social":{"ogDescription":"Discover Tiger Brokers HK, an online trading platform for stocks&ETFs, options&futures, bonds and crypto. Open an account to enjoy low commission trading today!","ogImage":"https://c1.itigergrowtha.com/portal5/static/media/og-logo.0a0bd8dc.png","ogUrl":"https://www.atigrnest.com/stock/IONS/filings?page=17"},"companyName":"Tiger Brokers"},"pageData":{"isMobile":false,"isTiger":false,"isTTM":true,"region":"HKG","license":"TBHK","edition":"fundamental","symbol":"IONS","isAnalysisPage":false},"__swrFallback__":{"@#url:\"https://hq.skytigris.cn/stock_info/detail/global\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","market":"US","secType":"STK","nameCN":"Ionis Pharmaceuticals","latestPrice":54.21,"timestamp":1789156800000,"preClose":55.65,"halted":0,"volume":2175778,"hourTrading":{"tag":"盘后","latestPrice":54.2,"preClose":54.21,"latestTime":"19:52 EDT","volume":114553,"amount":6238532.5464,"timestamp":1789170776940,"change":-0.01,"changeRate":-0.000184,"amplitude":0.001107},"delay":0,"changeRate":-0.025876010781671118,"floatShares":161921007,"shares":166184322,"eps":-3.48,"marketStatus":"Closed","change":-1.44,"latestTime":"09-11 16:00:00 EDT","open":55.94,"high":56.16,"low":54.16,"amount":119321699.87243,"amplitude":0.035939,"askPrice":0,"askSize":0,"bidPrice":0,"bidSize":0,"shortable":3,"etf":0,"ttmEps":-3.48,"tradingStatus":0,"nextMarketStatus":{"tag":"Pre-Mkt","tradingStatus":1,"beginTime":1789372800000},"marketStatusCode":5,"adr":0,"adrRate":0,"exchange":"NASDAQ","adjPreClose":55.65,"preHourTrading":{"tag":"盘前","latestPrice":55.97,"preClose":55.65,"latestTime":"09:29 EDT","volume":2574,"amount":143329.94676,"timestamp":1789133399999,"change":0.32,"changeRate":0.00575,"amplitude":0.018329},"postHourTrading":{"tag":"盘后","latestPrice":54.2,"preClose":54.21,"latestTime":"19:52 EDT","volume":114553,"amount":6238532.5464,"timestamp":1789170776940,"change":-0.01,"changeRate":-0.000184,"amplitude":0.001107},"volumeRatio":0.488066,"impliedVol":0.4195,"impliedVolPercentile":0.3745},"@#url:\"https://hq.skytigris.cn/stock_info/fundamental/all\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","floatShares":161921007,"roa":"-12.42%","roe":"-105.50%","lyrEps":-2.38125,"volumeRatio":0.488066,"shares":166184322,"dividePrice":0,"high":56.16,"amplitude":0.035939,"preClose":55.65,"low":54.16,"week52Low":50.005,"pbRate":"20.49","psRate":"10.31","week52High":86.74,"institutionHeld":0.92,"latestPrice":54.21,"eps":-3.48,"divideRate":0,"volume":2175778,"delay":0,"ttmEps":-3.48,"open":55.94,"prevYearClose":79.11,"prevWeekClose":58.09,"prevMonthClose":60.36,"prevQuarterClose":79.29,"fiveDayClose":58.13,"twentyDayClose":55.87,"sixtyDayClose":73.09},"@#url:\"https://hq.skytigris.cn/fundamental/corporate_actions/details/IONS\",params:#limit:5,,,undefined,":[{"market":"US","date":"2026-07-29","symbol":"IONS","fiscalQuarterEnding":"2026/06","expectedEps":-1.09,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1785297600000,"reportTimeType":"pre","actualEps":-0.7},{"market":"US","date":"2026-04-29","symbol":"IONS","fiscalQuarterEnding":"2026/03","expectedEps":-0.89,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1777435200000,"reportTimeType":"pre","actualEps":-0.56},{"market":"US","date":"2026-02-25","symbol":"IONS","fiscalQuarterEnding":"2025/12","expectedEps":-1.31,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1771995600000,"reportTimeType":"pre","actualEps":-1.41},{"market":"US","date":"2025-10-29","symbol":"IONS","fiscalQuarterEnding":"2025/09","expectedEps":-1.23,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1761710400000,"reportTimeType":"pre","actualEps":-0.8},{"market":"US","date":"2025-07-30","symbol":"IONS","fiscalQuarterEnding":"2025/06","expectedEps":-0.11,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1753848000000,"reportTimeType":"pre","actualEps":0.7}],"@#url:\"https://hq.skytigris.cn/fundamental/dividend/history\",params:#symbol:\"IONS\",market:\"US\",,,undefined,":[],"@#url:\"https://hq.skytigris.cn/fundamental/estimate/recommendation\",params:#symbol:\"IONS\",market:\"US\",delay:false,,,undefined,":{"strongBuy":0.2308,"buy":0.5385,"hold":0.2308,"sell":0,"strongSell":0,"meanLabel":"BUY","meanPercent":0.5385,"analysts":26,"updateTime":1787112000000},"@#url:\"https://hq.skytigris.cn/value_analysis/stock/IONS\",params:#withQuantilePoint:true,period:\"5year\",factor:\"peRate\",delay:false,algorithm:1,,,undefined,":{"brief":{"id":"IONS","date":"2026-09-10","current":-15.577586,"percent":0.65419,"low":-1664.931905,"twenty":-46.83029,"median":-17.982683,"eighty":-11.673442,"high":882.260453,"avg":-65.167353,"sd":366.235883,"marketCap":9309645718},"quantilePoints":[{"date":"2021-09-17","current":-9.553748,"twenty":-43.823694,"median":22.105712,"eighty":90.484478,"marketCap":5252105842},{"date":"2021-09-24","current":-9.294428,"twenty":-43.823694,"median":21.894477,"eighty":89.822908,"marketCap":5109546667},{"date":"2021-10-01","current":-8.61917,"twenty":-43.823694,"median":21.739571,"eighty":88.160122,"marketCap":4738328221},{"date":"2021-10-08","current":-8.752681,"twenty":-43.823694,"median":21.475528,"eighty":87.371554,"marketCap":4811725024},{"date":"2021-10-15","current":-9.012001,"twenty":-43.823694,"median":21.145012,"eighty":86.264015,"marketCap":4954284199},{"date":"2021-10-22","current":-7.815535,"twenty":-43.823694,"median":21.004285,"eighty":84.663252,"marketCap":4296535927},{"date":"2021-10-29","current":-8.182691,"twenty":-43.823694,"median":20.82218,"eighty":83.19244,"marketCap":4498377135},{"date":"2021-11-05","current":-7.827936,"twenty":-43.823694,"median":20.669316,"eighty":82.070133,"marketCap":4757365405},{"date":"2021-11-12","current":-7.595584,"twenty":-43.823694,"median":20.616507,"eighty":76.079084,"marketCap":4616155390},{"date":"2021-11-19","current":-7.432938,"twenty":-43.823694,"median":20.366546,"eighty":75.49578,"marketCap":4517308379},{"date":"2021-11-26","current":-6.749823,"twenty":-43.823694,"median":20.294106,"eighty":74.547727,"marketCap":4102150935},{"date":"2021-12-03","current":-6.131767,"twenty":-43.823694,"median":20.173015,"eighty":74.030875,"marketCap":3726532295},{"date":"2021-12-10","current":-6.847411,"twenty":-43.823694,"median":20.114106,"eighty":72.607318,"marketCap":4161459142},{"date":"2021-12-17","current":-7.542143,"twenty":-43.823694,"median":20.025743,"eighty":70.436541,"marketCap":4583677086},{"date":"2021-12-23","current":-7.600231,"twenty":-43.823694,"median":19.891562,"eighty":60.214071,"marketCap":4618979590},{"date":"2021-12-31","current":-7.070469,"twenty":-43.823694,"median":19.796653,"eighty":53.012098,"marketCap":4297020756},{"date":"2022-01-07","current":-7.058851,"twenty":-43.611673,"median":19.749198,"eighty":51.923862,"marketCap":4289960255},{"date":"2022-01-14","current":-7.686201,"twenty":-43.611673,"median":19.64938,"eighty":51.147099,"marketCap":4671227296},{"date":"2022-01-21","current":-6.942675,"twenty":-43.611673,"median":19.61175,"eighty":50.934296,"marketCap":4219355248},{"date":"2022-01-28","current":-7.360909,"twenty":-43.611673,"median":19.468798,"eighty":50.847883,"marketCap":4473533275},{"date":"2022-02-04","current":-7.319085,"twenty":-43.611673,"median":19.28882,"eighty":50.5876,"marketCap":4448115472},{"date":"2022-02-11","current":-7.639731,"twenty":-43.611673,"median":19.164904,"eighty":50.143461,"marketCap":4642985293},{"date":"2022-02-18","current":-7.497996,"twenty":-43.611673,"median":18.965356,"eighty":49.908881,"marketCap":4556847184},{"date":"2022-02-25","current":-157.459445,"twenty":-44.533501,"median":18.77393,"eighty":49.713145,"marketCap":4502867744},{"date":"2022-03-04","current":-160.035874,"twenty":-45.829592,"median":18.155386,"eighty":49.32903,"marketCap":4576545882},{"date":"2022-03-11","current":-159.49086,"twenty":-46.633425,"median":-6.144547,"eighty":48.69515,"marketCap":4560960122},{"date":"2022-03-18","current":-174.652153,"twenty":-47.12015,"median":-6.881102,"eighty":48.427938,"marketCap":4994527626},{"date":"2022-03-25","current":-181.687786,"twenty":-47.927671,"median":-7.000763,"eighty":48.265452,"marketCap":5195725619},{"date":"2022-04-01","current":-192.736702,"twenty":-48.230031,"median":-7.040263,"eighty":47.833218,"marketCap":5511691480},{"date":"2022-04-08","current":-198.781401,"twenty":-48.689101,"median":-7.082087,"eighty":47.228668,"marketCap":5684551727},{"date":"2022-04-14","current":-202.992871,"twenty":-49.716018,"median":-7.119262,"eighty":46.918857,"marketCap":5804987145},{"date":"2022-04-22","current":-206.852389,"twenty":-50.435043,"median":-7.237762,"eighty":46.570634,"marketCap":5915357781},{"date":"2022-04-29","current":-182.216483,"twenty":-51.591015,"median":-7.300497,"eighty":46.245658,"marketCap":5210844764},{"date":"2022-05-06","current":-1322.183946,"twenty":-128.214398,"median":-7.341159,"eighty":45.925265,"marketCap":5147262100},{"date":"2022-05-13","current":-1314.170709,"twenty":-130.326929,"median":-7.37485,"eighty":45.90793,"marketCap":5116066572},{"date":"2022-05-20","current":-1438.375868,"twenty":-130.86667,"median":-7.37485,"eighty":45.90793,"marketCap":5599597254},{"date":"2022-05-27","current":-1370.6276,"twenty":-132.625178,"median":-7.37485,"eighty":45.90793,"marketCap":5335853246},{"date":"2022-06-03","current":-1316.720376,"twenty":-134.128325,"median":-7.37485,"eighty":45.90793,"marketCap":5125992422},{"date":"2022-06-10","current":-1266.091293,"twenty":-137.45382,"median":-7.37485,"eighty":45.90793,"marketCap":4928893405},{"date":"2022-06-17","current":-1284.303193,"twenty":-139.005646,"median":-7.37485,"eighty":45.90793,"marketCap":4999792332},{"date":"2022-06-24","current":-1429.634156,"twenty":-139.862338,"median":-7.360909,"eighty":45.909339,"marketCap":5565565769},{"date":"2022-07-01","current":-1386.289834,"twenty":-141.353878,"median":-7.360909,"eighty":45.909339,"marketCap":5396826323},{"date":"2022-07-08","current":-1353.144176,"twenty":-142.456573,"median":-7.360909,"eighty":45.909339,"marketCap":5267790276},{"date":"2022-07-15","current":-1431.819584,"twenty":-143.808127,"median":-7.360909,"eighty":45.909339,"marketCap":5574073640},{"date":"2022-07-22","current":-1387.746786,"twenty":-144.656772,"median":-7.360909,"eighty":45.909339,"marketCap":5402498237},{"date":"2022-07-29","current":-1368.077934,"twenty":-146.022974,"median":-7.360909,"eighty":45.909339,"marketCap":5325927396},{"date":"2022-08-05","current":-1664.567667,"twenty":-147.819198,"median":-7.360909,"eighty":45.909339,"marketCap":6480161927},{"date":"2022-08-12","current":-222.342663,"twenty":-148.698169,"median":-7.360909,"eighty":45.909339,"marketCap":6259613005},{"date":"2022-08-19","current":-221.838485,"twenty":-149.407406,"median":-7.360909,"eighty":45.909339,"marketCap":6245418872},{"date":"2022-08-26","current":-213.519542,"twenty":-149.883165,"median":-7.360909,"eighty":45.909339,"marketCap":6011215664},{"date":"2022-09-02","current":-218.006729,"twenty":-150.165357,"median":-7.360909,"eighty":45.909339,"marketCap":6137543455},{"date":"2022-09-09","current":-236.157151,"twenty":-151.092649,"median":-7.360909,"eighty":45.909339,"marketCap":6648532271},{"date":"2022-09-16","current":-233.585841,"twenty":-153.529951,"median":-7.360909,"eighty":45.909339,"marketCap":6576142189},{"date":"2022-09-23","current":-217.956312,"twenty":-156.46647,"median":-7.360909,"eighty":45.909339,"marketCap":6136124041},{"date":"2022-09-30","current":-222.998095,"twenty":-157.969129,"median":-7.360909,"eighty":45.909339,"marketCap":6278065379},{"date":"2022-10-07","current":-231.569128,"twenty":-159.577078,"median":-7.360909,"eighty":45.909339,"marketCap":6519365654},{"date":"2022-10-14","current":-233.737095,"twenty":-160.082841,"median":-7.360909,"eighty":45.909339,"marketCap":6580400429},{"date":"2022-10-21","current":-226.62818,"twenty":-160.43291,"median":-7.360909,"eighty":45.909339,"marketCap":6380263143},{"date":"2022-10-28","current":-224.913973,"twenty":-161.94987,"median":-7.360909,"eighty":45.909339,"marketCap":6332003088},{"date":"2022-11-04","current":-209.486115,"twenty":-162.370971,"median":-7.360909,"eighty":45.909339,"marketCap":5897662593},{"date":"2022-11-11","current":839.185498,"twenty":-162.756411,"median":-7.319085,"eighty":46.031035,"marketCap":6143677032},{"date":"2022-11-18","current":836.080997,"twenty":-162.756411,"median":-7.284232,"eighty":46.34415,"marketCap":6120948978},{"date":"2022-11-25","current":806.394204,"twenty":-162.756411,"median":-7.219174,"eighty":46.64061,"marketCap":5903611964},{"date":"2022-12-02","current":782.334319,"twenty":-162.756411,"median":-7.102998,"eighty":47.141347,"marketCap":5727469547},{"date":"2022-12-09","current":727.617484,"twenty":-162.756411,"median":-7.058851,"eighty":47.387939,"marketCap":5326887600},{"date":"2022-12-16","current":750.125118,"twenty":-162.756411,"median":-7.014704,"eighty":48.047842,"marketCap":5491665989},{"date":"2022-12-23","current":740.423552,"twenty":-162.756411,"median":-6.972881,"eighty":48.293594,"marketCap":5420640821},{"date":"2022-12-30","current":732.85633,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5365241190},{"date":"2023-01-06","current":786.214945,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5755879614},{"date":"2023-01-13","current":773.214846,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5660705889},{"date":"2023-01-20","current":790.871697,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5789971695},{"date":"2023-01-27","current":776.513379,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5684854446},{"date":"2023-02-03","current":793.976198,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5812699749},{"date":"2023-02-10","current":756.722183,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5539963104},{"date":"2023-02-17","current":748.96093,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5483142969},{"date":"2023-02-24","current":-18.915876,"twenty":-162.756411,"median":-6.942675,"eighty":48.318169,"marketCap":5102028010},{"date":"2023-03-03","current":-19.398181,"twenty":-162.756411,"median":-7.010057,"eighty":48.167441,"marketCap":5232116143},{"date":"2023-03-10","current":-17.998968,"twenty":-162.756411,"median":-7.047233,"eighty":47.522459,"marketCap":4854717602},{"date":"2023-03-17","current":-18.645574,"twenty":-162.756411,"median":-7.096027,"eighty":47.151665,"marketCap":5029121473},{"date":"2023-03-24","current":-17.993668,"twenty":-162.756411,"median":-7.188968,"eighty":46.719576,"marketCap":4853288062},{"date":"2023-03-31","current":-18.942377,"twenty":-162.739653,"median":-7.283071,"eighty":46.447558,"marketCap":5109175709},{"date":"2023-04-06","current":-19.392881,"twenty":-162.739653,"median":-7.309791,"eighty":46.139197,"marketCap":5230686603},{"date":"2023-04-14","current":-19.906986,"twenty":-162.756411,"median":-7.388791,"eighty":45.881909,"marketCap":5369351977},{"date":"2023-04-21","current":-19.158378,"twenty":-162.756411,"median":-7.484055,"eighty":45.586713,"marketCap":5167435947},{"date":"2023-04-28","current":-18.691747,"twenty":-162.756411,"median":-7.542143,"eighty":45.238708,"marketCap":5041575343},{"date":"2023-05-05","current":-15.654507,"twenty":-162.722895,"median":-7.581643,"eighty":45.096531,"marketCap":5148454369},{"date":"2023-05-12","current":-15.484823,"twenty":-162.005118,"median":-7.581643,"eighty":45.096531,"marketCap":5092648444},{"date":"2023-05-19","current":-15.937315,"twenty":-160.611822,"median":-7.581643,"eighty":45.096531,"marketCap":5241464245},{"date":"2023-05-26","current":-17.042442,"twenty":-160.205418,"median":-7.581643,"eighty":45.096531,"marketCap":5604918222},{"date":"2023-06-02","current":-18.682728,"twenty":-159.773437,"median":-7.581643,"eighty":45.096531,"marketCap":6144375503},{"date":"2023-06-09","current":-18.121463,"twenty":-159.192484,"median":-7.581643,"eighty":45.096531,"marketCap":5959786673},{"date":"2023-06-16","current":-18.138866,"twenty":-156.985977,"median":-7.581643,"eighty":45.096531,"marketCap":5965510357},{"date":"2023-06-23","current":-17.925673,"twenty":-155.435521,"median":-7.578157,"eighty":45.109315,"marketCap":5895395220},{"date":"2023-06-30","current":-17.886515,"twenty":-151.740635,"median":-7.574672,"eighty":45.122099,"marketCap":5882516929},{"date":"2023-07-07","current":-18.169323,"twenty":-150.657265,"median":-7.574672,"eighty":45.122099,"marketCap":5975526805},{"date":"2023-07-14","current":-18.560903,"twenty":-150.083568,"median":-7.574672,"eighty":45.122099,"marketCap":6104309711},{"date":"2023-07-21","current":-17.821251,"twenty":-149.641501,"median":-7.574672,"eighty":45.122099,"marketCap":5861053112},{"date":"2023-07-28","current":-16.750932,"twenty":-149.090615,"median":-7.574672,"eighty":45.122099,"marketCap":5509046504},{"date":"2023-08-04","current":-17.151214,"twenty":-148.303568,"median":-7.574672,"eighty":45.122099,"marketCap":5640691252},{"date":"2023-08-11","current":-18.467972,"twenty":-148.00823,"median":-7.574672,"eighty":45.122099,"marketCap":5707249602},{"date":"2023-08-18","current":-18.147959,"twenty":-147.735407,"median":-7.574672,"eighty":45.122099,"marketCap":5608354519},{"date":"2023-08-25","current":-18.463334,"twenty":-145.579013,"median":-7.574672,"eighty":45.122099,"marketCap":5705816340},{"date":"2023-09-01","current":-18.676675,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5771746396},{"date":"2023-09-08","current":-18.727692,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5787512279},{"date":"2023-09-15","current":-20.239635,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":6254755717},{"date":"2023-09-22","current":-19.701643,"twenty":-144.797122,"median":-7.574672,"eighty":45.122099,"marketCap":6088497315},{"date":"2023-09-29","current":-21.454756,"twenty":-143.400598,"median":-7.574672,"eighty":45.122099,"marketCap":6630270382},{"date":"2023-10-06","current":-21.728389,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6714832844},{"date":"2023-10-13","current":-21.38055,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6607338188},{"date":"2023-10-20","current":-21.593891,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6673268244},{"date":"2023-10-27","current":-21.16257,"twenty":-143.300049,"median":-7.55957,"eighty":45.146419,"marketCap":6539974871},{"date":"2023-11-03","current":-15.297336,"twenty":-140.032184,"median":-7.55957,"eighty":45.146419,"marketCap":6267655075},{"date":"2023-11-10","current":-16.577399,"twenty":-22.395314,"median":-7.55957,"eighty":45.146419,"marketCap":6787665949},{"date":"2023-11-17","current":-17.008391,"twenty":-21.672735,"median":-7.55957,"eighty":45.146419,"marketCap":6964136656},{"date":"2023-11-24","current":-17.460406,"twenty":-21.484438,"median":-7.55957,"eighty":45.146419,"marketCap":7149215689},{"date":"2023-12-01","current":-17.334262,"twenty":-21.2275,"median":-7.55957,"eighty":45.146419,"marketCap":7097565726},{"date":"2023-12-08","current":-17.334262,"twenty":-20.411236,"median":-7.572349,"eighty":45.140651,"marketCap":7097565726},{"date":"2023-12-15","current":-17.456902,"twenty":-20.127399,"median":-7.572349,"eighty":45.140651,"marketCap":7147780968},{"date":"2023-12-22","current":-17.208119,"twenty":-19.907658,"median":-7.572349,"eighty":45.140651,"marketCap":7045915764},{"date":"2023-12-29","current":-17.695174,"twenty":-19.76602,"median":-7.55957,"eighty":45.146419,"marketCap":7245342009},{"date":"2024-01-05","current":-18.038565,"twenty":-19.665059,"median":-7.54679,"eighty":45.152187,"marketCap":7385944686},{"date":"2024-01-12","current":-18.763892,"twenty":-19.458602,"median":-7.54679,"eighty":45.152187,"marketCap":7682931972},{"date":"2024-01-19","current":-17.747734,"twenty":-19.2678,"median":-7.544467,"eighty":45.157955,"marketCap":7266862827},{"date":"2024-01-26","current":-18.073605,"twenty":-19.134896,"median":-7.54679,"eighty":45.152187,"marketCap":7400291898},{"date":"2024-02-02","current":-17.859862,"twenty":-19.007278,"median":-7.54679,"eighty":45.152187,"marketCap":7312773905},{"date":"2024-02-09","current":-17.512966,"twenty":-18.941814,"median":-7.54679,"eighty":45.152187,"marketCap":7170736507},{"date":"2024-02-16","current":-15.866089,"twenty":-18.881956,"median":-7.54679,"eighty":45.152187,"marketCap":6496417548},{"date":"2024-02-23","current":-17.500434,"twenty":-18.811317,"median":-7.54679,"eighty":45.152187,"marketCap":6410164032},{"date":"2024-03-01","current":-17.989873,"twenty":-18.791838,"median":-7.578157,"eighty":45.146419,"marketCap":6589438742},{"date":"2024-03-08","current":-17.774998,"twenty":-18.791838,"median":-7.603716,"eighty":45.146419,"marketCap":6510732771},{"date":"2024-03-15","current":-16.784182,"twenty":-18.791838,"median":-7.673842,"eighty":45.146419,"marketCap":6147810797},{"date":"2024-03-22","current":-17.010995,"twenty":-18.791838,"median":-7.777023,"eighty":45.146419,"marketCap":6230889321},{"date":"2024-03-28","current":-17.771018,"twenty":-18.791838,"median":-7.81825,"eighty":45.146419,"marketCap":6509275254},{"date":"2024-04-05","current":-17.042828,"twenty":-18.796083,"median":-7.904612,"eighty":45.152187,"marketCap":6242549465},{"date":"2024-04-12","current":-16.911516,"twenty":-18.796083,"median":-8.182691,"eighty":45.152187,"marketCap":6194451372},{"date":"2024-04-19","current":-16.239034,"twenty":-18.796083,"median":-8.560117,"eighty":45.152187,"marketCap":5948130835},{"date":"2024-04-26","current":-16.659633,"twenty":-18.791838,"median":-8.646128,"eighty":45.146419,"marketCap":6102190447},{"date":"2024-05-03","current":-17.157352,"twenty":-18.791838,"median":-8.845112,"eighty":45.146419,"marketCap":6284497762},{"date":"2024-05-10","current":-14.961134,"twenty":-18.791838,"median":-9.293144,"eighty":45.146419,"marketCap":5756535778},{"date":"2024-05-17","current":-14.25989,"twenty":-18.791838,"median":-9.334225,"eighty":45.146419,"marketCap":5486720952},{"date":"2024-05-24","current":-14.40393,"twenty":-18.791838,"median":-9.552464,"eighty":45.146419,"marketCap":5542142376},{"date":"2024-05-31","current":-13.854306,"twenty":-18.791838,"median":-9.739892,"eighty":45.146419,"marketCap":5330665890},{"date":"2024-06-07","current":-15.112755,"twenty":-18.791838,"median":-9.90935,"eighty":45.146419,"marketCap":5814874119},{"date":"2024-06-14","current":-15.586568,"twenty":-18.796083,"median":-9.987659,"eighty":45.152187,"marketCap":5997181434},{"date":"2024-06-21","current":-15.469062,"twenty":-18.800329,"median":-10.068299,"eighty":45.157955,"marketCap":5951969220},{"date":"2024-06-28","current":-17.902568,"twenty":-18.809069,"median":-10.099656,"eighty":45.171414,"marketCap":6888299589},{"date":"2024-07-05","current":-17.284716,"twenty":-18.809069,"median":-10.146845,"eighty":45.171414,"marketCap":6650570851},{"date":"2024-07-12","current":-17.932892,"twenty":-18.809069,"median":-10.187925,"eighty":45.171414,"marketCap":6899967258},{"date":"2024-07-15","current":-18.194437,"twenty":-18.809069,"median":-10.208466,"eighty":45.171414,"marketCap":7000600896},{"date":"2024-08-02","current":-20.490271,"twenty":-18.868176,"median":-10.389456,"eighty":45.307924,"marketCap":7484809124},{"date":"2024-08-09","current":-18.992918,"twenty":-18.884076,"median":-10.451704,"eighty":45.307924,"marketCap":6946488933},{"date":"2024-08-16","current":-18.655115,"twenty":-18.884076,"median":-10.488762,"eighty":45.307924,"marketCap":6822940561},{"date":"2024-08-23","current":-19.004911,"twenty":-18.92096,"median":-10.554325,"eighty":45.307924,"marketCap":6950875266},{"date":"2024-08-30","current":-19.948361,"twenty":-18.942377,"median":-10.636992,"eighty":45.307924,"marketCap":7295933440},{"date":"2024-09-06","current":-19.248769,"twenty":-18.979477,"median":-10.675476,"eighty":45.307924,"marketCap":7040064031},{"date":"2024-09-13","current":-17.667381,"twenty":-18.992918,"median":-10.762419,"eighty":45.307924,"marketCap":6461685590},{"date":"2024-09-20","current":-18.408188,"twenty":-18.992918,"median":-10.826557,"eighty":45.307924,"marketCap":6732629014},{"date":"2024-09-27","current":-17.701837,"twenty":-18.992918,"median":-11.068858,"eighty":45.307924,"marketCap":6474287610},{"date":"2024-10-04","current":-16.284829,"twenty":-18.992918,"median":-11.242743,"eighty":45.307924,"marketCap":5956029551},{"date":"2024-10-11","current":-16.345127,"twenty":-18.992918,"median":-12.040191,"eighty":45.307924,"marketCap":5978083085},{"date":"2024-10-18","current":-16.577706,"twenty":-18.992918,"median":-13.03948,"eighty":45.307924,"marketCap":6063146718},{"date":"2024-10-25","current":-16.698302,"twenty":-18.992918,"median":-13.446915,"eighty":45.307924,"marketCap":6107253787},{"date":"2024-10-31","current":-16.909346,"twenty":-18.992918,"median":-13.562755,"eighty":45.307924,"marketCap":6184441157},{"date":"2024-11-08","current":-16.902216,"twenty":-18.995317,"median":-13.748329,"eighty":45.31946,"marketCap":6072729658},{"date":"2024-11-15","current":-16.383322,"twenty":-18.995317,"median":-13.840323,"eighty":45.31946,"marketCap":5878515995},{"date":"2024-11-22","current":-14.935534,"twenty":-18.995317,"median":-14.176174,"eighty":45.31946,"marketCap":5359033920},{"date":"2024-11-29","current":-15.723236,"twenty":-18.995317,"median":-14.25989,"eighty":45.31946,"marketCap":5641670064},{"date":"2024-12-06","current":-16.172094,"twenty":-18.995317,"median":-14.506273,"eighty":45.31946,"marketCap":5802725297},{"date":"2024-12-13","current":-16.286509,"twenty":-18.995317,"median":-14.813304,"eighty":45.31946,"marketCap":5843778591},{"date":"2024-12-20","current":-15.661628,"twenty":-18.995317,"median":-14.935534,"eighty":45.31946,"marketCap":5619564444},{"date":"2024-12-27","current":-15.98727,"twenty":-18.995317,"median":-15.08243,"eighty":45.31946,"marketCap":5736408436},{"date":"2025-01-03","current":-15.265577,"twenty":-18.995317,"median":-15.112755,"eighty":45.31946,"marketCap":5477456886},{"date":"2025-01-10","current":-15.005943,"twenty":-18.997715,"median":-15.244128,"eighty":45.330996,"marketCap":5384297486},{"date":"2025-01-17","current":-14.205039,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5096924424},{"date":"2025-01-24","current":-15.164364,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5441140510},{"date":"2025-01-31","current":-14.662699,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5261137602},{"date":"2025-02-07","current":-14.359059,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5152188474},{"date":"2025-02-14","current":-13.35573,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4792182660},{"date":"2025-02-21","current":-11.446164,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5196558396},{"date":"2025-02-28","current":-10.979464,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4983545602},{"date":"2025-03-07","current":-12.044139,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5466798509},{"date":"2025-03-14","current":-11.522308,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5229940998},{"date":"2025-03-21","current":-11.46277,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5202916987},{"date":"2025-03-28","current":-11.109046,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5042362567},{"date":"2025-04-04","current":-9.988335,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4533675297},{"date":"2025-04-11","current":-9.354433,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4245949060},{"date":"2025-04-17","current":-9.928797,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4506651286},{"date":"2025-04-25","current":-10.356068,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4700588308},{"date":"2025-05-02","current":-11.018739,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5046935029},{"date":"2025-05-09","current":-11.380123,"twenty":-19.000114,"median":-15.297336,"eighty":45.26178,"marketCap":5212460492},{"date":"2025-05-16","current":-11.463519,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5250658676},{"date":"2025-05-23","current":-11.55734,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5293631632},{"date":"2025-05-30","current":-11.626837,"twenty":-19.000114,"median":-15.297336,"eighty":45.007986,"marketCap":5325463452},{"date":"2025-06-06","current":-12.24536,"twenty":-19.000114,"median":-15.297336,"eighty":44.117786,"marketCap":5608766648},{"date":"2025-06-13","current":-12.377404,"twenty":-19.000114,"median":-15.297336,"eighty":-6.098308,"marketCap":5669247106},{"date":"2025-06-20","current":-12.860408,"twenty":-19.002512,"median":-15.301886,"eighty":-6.769341,"marketCap":5890478253},{"date":"2025-06-27","current":-13.82294,"twenty":-19.002512,"median":-15.301886,"eighty":-6.989146,"marketCap":6331348958},{"date":"2025-07-03","current":-14.941841,"twenty":-19.002512,"median":-15.301886,"eighty":-7.017492,"marketCap":6843841257},{"date":"2025-07-11","current":-14.7264,"twenty":-19.002512,"median":-15.301886,"eighty":-7.061175,"marketCap":6745162615},{"date":"2025-07-18","current":-14.653429,"twenty":-19.002512,"median":-15.301886,"eighty":-7.105786,"marketCap":6711739204},{"date":"2025-07-25","current":-14.646479,"twenty":-19.002512,"median":-15.301886,"eighty":-7.221033,"marketCap":6708556022},{"date":"2025-08-01","current":-25.541485,"twenty":-19.026904,"median":-15.342587,"eighty":-7.288415,"marketCap":6850635022},{"date":"2025-08-08","current":-24.394555,"twenty":-19.059439,"median":-15.406519,"eighty":-7.31955,"marketCap":6543009950},{"date":"2025-08-15","current":-25.464231,"twenty":-19.208439,"median":-15.476942,"eighty":-7.439444,"marketCap":6829914162},{"date":"2025-08-22","current":-25.693023,"twenty":-19.327123,"median":-15.573133,"eighty":-7.500784,"marketCap":6891279785},{"date":"2025-08-29","current":-25.32755,"twenty":-19.462842,"median":-15.656683,"eighty":-7.572814,"marketCap":6793254179},{"date":"2025-09-05","current":-35.269594,"twenty":-19.610183,"median":-15.723236,"eighty":-7.595584,"marketCap":9459869441},{"date":"2025-09-12","current":-38.056694,"twenty":-19.731561,"median":-15.763036,"eighty":-7.642541,"marketCap":10207414305},{"date":"2025-09-19","current":-36.689886,"twenty":-19.905803,"median":-15.876073,"eighty":-7.741966,"marketCap":9840814478},{"date":"2025-09-26","current":-37.420831,"twenty":-20.021346,"median":-16.03996,"eighty":-7.801291,"marketCap":10036865690},{"date":"2025-10-03","current":-40.647687,"twenty":-20.250766,"median":-16.203648,"eighty":-7.855354,"marketCap":10902360063},{"date":"2025-10-10","current":-41.758962,"twenty":-20.936243,"median":-16.267488,"eighty":-8.057965,"marketCap":11200421661},{"date":"2025-10-17","current":-43.422902,"twenty":-21.44548,"median":-16.302057,"eighty":-8.466659,"marketCap":11646717103},{"date":"2025-10-24","current":-42.489907,"twenty":-21.627284,"median":-16.365719,"eighty":-8.619683,"marketCap":11396472873},{"date":"2025-10-31","current":-46.865674,"twenty":-22.311833,"median":-16.491552,"eighty":-8.824572,"marketCap":12013640728},{"date":"2025-11-07","current":-46.821444,"twenty":-24.565703,"median":-16.551864,"eighty":-9.220997,"marketCap":12002302521},{"date":"2025-11-14","current":-44.129685,"twenty":-25.310911,"median":-16.577552,"eighty":-9.310347,"marketCap":11312291607},{"date":"2025-11-21","current":-46.202213,"twenty":-25.459477,"median":-16.623152,"eighty":-9.406991,"marketCap":11843567616},{"date":"2025-11-28","current":-52.274467,"twenty":-25.606854,"median":-16.659586,"eighty":-9.54788,"marketCap":13400141532},{"date":"2025-12-05","current":-51.693149,"twenty":-25.977676,"median":-16.714478,"eighty":-9.709339,"marketCap":13251125091},{"date":"2025-12-12","current":-50.00606,"twenty":-36.254884,"median":-16.738094,"eighty":-9.817591,"marketCap":12818653462},{"date":"2025-12-19","current":-49.051939,"twenty":-36.458718,"median":-16.773398,"eighty":-9.930898,"marketCap":12574072128},{"date":"2025-12-26","current":-50.960181,"twenty":-37.51116,"median":-16.804783,"eighty":-9.964551,"marketCap":13063234795},{"date":"2026-01-02","current":-49.987104,"twenty":-38.080464,"median":-16.872737,"eighty":-9.994875,"marketCap":12813794230},{"date":"2026-01-09","current":-51.522544,"twenty":-40.33867,"median":-16.913584,"eighty":-10.055281,"marketCap":13207392005},{"date":"2026-01-16","current":-48.786554,"twenty":-41.579494,"median":-16.936559,"eighty":-10.101905,"marketCap":12506042883},{"date":"2026-01-23","current":-51.680511,"twenty":-42.352038,"median":-16.969214,"eighty":-10.147872,"marketCap":13247885603},{"date":"2026-01-30","current":-53.001116,"twenty":-43.304049,"median":-17.016336,"eighty":-10.177655,"marketCap":13586412084},{"date":"2026-02-06","current":-52.748369,"twenty":-43.896106,"median":-17.042828,"eighty":-10.276361,"marketCap":13521622327},{"date":"2026-02-13","current":-51.674193,"twenty":-45.89007,"median":-17.08842,"eighty":-10.365331,"marketCap":13246265859},{"date":"2026-02-20","current":-52.536693,"twenty":-46.437268,"median":-17.113581,"eighty":-10.415699,"marketCap":13467360905},{"date":"2026-02-27","current":-34.265449,"twenty":-46.808807,"median":-17.154283,"eighty":-10.419492,"marketCap":13055136075},{"date":"2026-03-06","current":-32.554417,"twenty":-46.808807,"median":-17.180856,"eighty":-10.419492,"marketCap":12415831546},{"date":"2026-03-13","current":-31.332977,"twenty":-46.808807,"median":-17.209871,"eighty":-10.419492,"marketCap":11949990075},{"date":"2026-03-20","current":-30.891179,"twenty":-46.808807,"median":-17.218631,"eighty":-10.419492,"marketCap":11781494224},{"date":"2026-03-27","current":-32.155933,"twenty":-46.808807,"median":-17.24834,"eighty":-10.419492,"marketCap":12263854896},{"date":"2026-04-02","current":-32.541423,"twenty":-46.808807,"median":-17.287579,"eighty":-10.419492,"marketCap":12410875786},{"date":"2026-04-10","current":-33.104499,"twenty":-46.808807,"median":-17.33251,"eighty":-10.419492,"marketCap":12625625400},{"date":"2026-04-17","current":-32.597731,"twenty":-46.808807,"median":-17.370954,"eighty":-10.419492,"marketCap":12432350747},{"date":"2026-04-24","current":-32.090963,"twenty":-46.808807,"median":-17.417852,"eighty":-10.419492,"marketCap":12239076094},{"date":"2026-05-01","current":-37.78562,"twenty":-46.808807,"median":-17.460406,"eighty":-10.419492,"marketCap":12355028686},{"date":"2026-05-08","current":-38.422456,"twenty":-46.808807,"median":-17.499692,"eighty":-10.425443,"marketCap":12563259507},{"date":"2026-05-15","current":-38.250612,"twenty":-46.808807,"median":-17.54086,"eighty":-10.441583,"marketCap":12507070238},{"date":"2026-05-22","current":-38.301154,"twenty":-46.808807,"median":-17.626193,"eighty":-10.45769,"marketCap":12523596493},{"date":"2026-05-29","current":-39.084564,"twenty":-46.821444,"median":-17.65446,"eighty":-10.515842,"marketCap":12779753455},{"date":"2026-06-05","current":-37.972628,"twenty":-46.808807,"median":-17.690774,"eighty":-10.584827,"marketCap":12416175832},{"date":"2026-06-12","current":-37.31052,"twenty":-46.808807,"median":-17.738974,"eighty":-10.668419,"marketCap":12199681883},{"date":"2026-06-18","current":-37.558179,"twenty":-46.808807,"median":-17.769888,"eighty":-10.69486,"marketCap":12280660536},{"date":"2026-06-26","current":-39.595044,"twenty":-46.821444,"median":-17.818766,"eighty":-10.726786,"marketCap":12946668637},{"date":"2026-07-02","current":-40.024656,"twenty":-46.821444,"median":-17.854581,"eighty":-10.726786,"marketCap":13087141809},{"date":"2026-07-10","current":-32.483705,"twenty":-46.821444,"median":-17.871767,"eighty":-10.726786,"marketCap":10621424474},{"date":"2026-07-17","current":-27.621511,"twenty":-46.821444,"median":-17.880886,"eighty":-10.979464,"marketCap":9031598685},{"date":"2026-07-24","current":-28.23813,"twenty":-46.821444,"median":-17.925673,"eighty":-11.109046,"marketCap":9233219003},{"date":"2026-07-31","current":-15.666504,"twenty":-46.83029,"median":-17.93492,"eighty":-11.257113,"marketCap":8854300676},{"date":"2026-08-07","current":-16.022293,"twenty":-46.83029,"median":-17.93492,"eighty":-11.326236,"marketCap":9055383705},{"date":"2026-08-14","current":-16.42807,"twenty":-46.83029,"median":-17.93492,"eighty":-11.457268,"marketCap":9284718070},{"date":"2026-08-21","current":-17.277849,"twenty":-46.83029,"median":-17.93492,"eighty":-11.52511,"marketCap":9764990760},{"date":"2026-08-28","current":-18.356979,"twenty":-46.83029,"median":-17.973741,"eighty":-11.565738,"marketCap":10374887222},{"date":"2026-09-04","current":-17.092603,"twenty":-46.83029,"median":-17.982683,"eighty":-11.643516,"marketCap":9660294637},{"date":"2026-09-10","current":-16.472176,"twenty":-46.83029,"median":-17.982683,"eighty":-11.673442,"marketCap":9309645718}],"updateTime":1789176299276},"$inf$@#url:\"https://stock-news.skytigris.cn/v3/notice/important/events/list\",params:#symbol:\"IONS\",pageSize:20,pageCount:17,market:\"us\",,,undefined,":[{"items":[{"cdn_pdf":false,"hasAttachments":true,"id":"11957842","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312521041468-IONS","pdf_url":null,"pub_time":1613059200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312521041468/0001193125-21-041468-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"SC 13G/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521041468/d129891dsc13ga.htm","primary":true,"translateUrl":null,"linkName":"d129891dsc13ga.htm","type":"SC 13G/A","id":"NTFILECupHTwR5gTVhUVAk","market":"us","size":51742}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2021-02-12 00:00","pubTimestamp":1613059200,"title_zh":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11957844","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465921018387-IONS","pdf_url":null,"pub_time":1612886400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000110465921018387/0001104659-21-018387-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"SCHEDULE 13G/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/102909/000110465921018387/tv01163-ionispharmaceuticals.htm","primary":true,"translateUrl":null,"linkName":"tv01163-ionispharmaceuticals.htm","type":"SC 13G/A","id":"NTFILEHyeL6HzMpJpYa7Xb","market":"us","size":12339}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2021-02-10 00:00","pubTimestamp":1612886400,"title_zh":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11780572","market":"us","labels":[],"media":"sec.gov","original_id":"AN134888321000018-IONS","pdf_url":null,"pub_time":1612800000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000134888321000018/0001348883-21-000018-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000134888321000018/ioni20a10.htm","primary":true,"translateUrl":null,"linkName":"ioni20a10.htm","type":"SC 13G/A","id":"NTFILEEye88yVsKG6qdy8g","market":"us","size":81767}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2021-02-09 00:00","pubTimestamp":1612800000,"title_zh":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":false,"id":"11780567","market":"us","labels":[],"media":"sec.gov","original_id":"AN31506621001069-IONS","pdf_url":null,"pub_time":1612713600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000031506621001069/0000315066-21-001069-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2021-02-08 00:00","pubTimestamp":1612713600,"title_zh":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":false,"id":"11780579","market":"us","labels":[],"media":"sec.gov","original_id":"AN83423721007434-IONS","pdf_url":null,"pub_time":1612454400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000083423721007434/0000834237-21-007434-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2021-02-05 00:00","pubTimestamp":1612454400,"title_zh":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11957845","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036121001189-IONS","pdf_url":null,"pub_time":1610553600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"CORRESP [Cover] - Correspondence","symbol":"IONS","title":"CORRESP [Cover] - Correspondence","titleType":"Correspondence","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036121001189/0001140361-21-001189-index.htm","us_notice_code":"Form CORRESP","us_title_en":"CORRESP [Cover] - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121001189/filename1.htm","primary":true,"translateUrl":null,"linkName":"filename1.htm","type":"CORRESP","id":"NTFILEFHvnykiqEkTFcQrH","market":"us","size":128161}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Correspondence","pubTime":"2021-01-14 00:00","pubTimestamp":1610553600,"title_zh":"CORRESP [Cover] - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11328157","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120030055-IONS","pdf_url":null,"pub_time":1609344000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"S-8  - Securities to be offered to employees in employee benefit plans","symbol":"IONS","title":"S-8  - Securities to be offered to employees in employee benefit plans","titleType":"Employee Stock Ownership","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/0001140361-20-030055-index.htm","us_notice_code":"Form S-8","us_title_en":"S-8  - Securities to be offered to employees in employee benefit plans","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"S-8","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_s8.htm","primary":true,"translateUrl":null,"linkName":"brhc10018560_s8.htm","type":"S-8","id":"NTFILE1kqo3aWZaeS49R7d","market":"us","size":67602},{"description":"EXHIBIT 5.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex5-1.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex5-1.htm","type":"EX-5.1","id":"NTFILEGwcqRLip3BPwHQGv","market":"us","size":5059},{"description":"EXHIBIT 23.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex23-1.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex23-1.htm","type":"EX-23.1","id":"NTFILE6SG1ndqy2KiZ5UDA","market":"us","size":2902},{"description":"EXHIBIT 99.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex99-1.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex99-1.htm","type":"EX-99.1","id":"NTFILECshz23CYn9Fa1Xjb","market":"us","size":118987},{"description":"EXHIBIT 99.2","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex99-2.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex99-2.htm","type":"EX-99.2","id":"NTFILE8FU5kcoJT4Hev11M","market":"us","size":84160},{"description":"EXHIBIT 99.3","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex99-3.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex99-3.htm","type":"EX-99.3","id":"NTFILE3ZQeAgiZ9SVdN11a","market":"us","size":92971},{"description":"EXHIBIT 99.4","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex99-4.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex99-4.htm","type":"EX-99.4","id":"NTFILE4y8zaCa3GTVFdL8D","market":"us","size":35017}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Employee Stock Ownership","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Employee Stock Ownership","pubTime":"2020-12-31 00:00","pubTimestamp":1609344000,"title_zh":"S-8  - Securities to be offered to employees in employee benefit plans","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11328153","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120028770-IONS","pdf_url":null,"pub_time":1608220800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120028770/0001140361-20-028770-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120028770/brhc10018098_ex99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10018098_ex99-1.htm","type":"EX-99.1","id":"NTFILEFEwJRcqPx56qqDYh","market":"us","size":9443},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120028770/brhc10018098_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10018098_8k.htm","type":"8-K","id":"NTFILEHG5kewdznATPkAZH","market":"us","size":26566},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120028770/image0.jpg","primary":false,"translateUrl":null,"linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILE8YM32YqfSnhgsExc","market":"us","size":11357}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2020-12-18 00:00","pubTimestamp":1608220800,"title_zh":"8-K  - Current report","summary_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11100041","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120027746-IONS","pdf_url":null,"pub_time":1607443200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120027746/0001140361-20-027746-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120027746/brhc10017778_ex99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10017778_ex99-1.htm","type":"EX-99.1","id":"NTFILED3D1nBeToz7pmn6V","market":"us","size":36658},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120027746/brhc10017778_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10017778_8k.htm","type":"8-K","id":"NTFILE3Um6izhQMAzhKUA5","market":"us","size":27296},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120027746/image0.jpg","primary":false,"translateUrl":null,"linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILEG5CXTduPTzwD3WMx","market":"us","size":11357}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2020-12-09 00:00","pubTimestamp":1607443200,"title_zh":"8-K  - Current report","summary_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10725268","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401520000142-IONS","pdf_url":null,"pub_time":1604419200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"10-Q  - Quarterly report [Sections 13 or 15(d)]","symbol":"IONS","title":"10-Q  - Quarterly report [Sections 13 or 15(d)]","titleType":"Quarterly Report","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/0000874015-20-000142-index.htm","us_notice_code":"Form 10-Q","us_title_en":"10-Q  - Quarterly report [Sections 13 or 15(d)]","is_important":0,"hasEarnInfos":true,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS INC 10-Q 9-30-2020","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/form10q.htm","primary":true,"translateUrl":null,"linkName":"form10q.htm","type":"10-Q","id":"NTFILEHQ985opxzCEcLYMR","market":"us","size":2670664},{"description":"EXHIBIT 31.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/ex31_1.htm","primary":false,"translateUrl":null,"linkName":"ex31_1.htm","type":"EX-31.1","id":"NTFILEFuFMiLnVQCzJ7toF","market":"us","size":13547},{"description":"EXHIBIT 31.2","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/ex31_2.htm","primary":false,"translateUrl":null,"linkName":"ex31_2.htm","type":"EX-31.2","id":"NTFILEJ6uApu6jqtqZiqDj","market":"us","size":13464},{"description":"EXHIBIT 32.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/ex32_1.htm","primary":false,"translateUrl":null,"linkName":"ex32_1.htm","type":"EX-32.1","id":"NTFILEDVRyQzfRxs7eMGvC","market":"us","size":7023}],"type_name":"Financial Report","type_name_en":"Financial Report","titleTypeEn":"Quarterly Report","us_type":"财务报告","us_type_zh":"财务报告","earn_infos":[{"id":47944,"name":"CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R2.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47945,"name":"CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R3.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47946,"name":"CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R4.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47947,"name":"CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R5.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47948,"name":"CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R6.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47949,"name":"CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited)","name_zh":"简明合并现金流量表（未经审计）","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R7.htm","cdn_url":"https://static.tigerbbs.com/3b7fe9c2ff49bf26bec185b55c4a2512","translation_url":"https://static.tigerbbs.com/05d98c42fde2bed64b38fefcd3d19711","translate_status":1}],"event_type":"important_notice","event_name":"Quarterly Report","pubTime":"2020-11-04 00:00","pubTimestamp":1604419200,"title_zh":"10-Q  - Quarterly report [Sections 13 or 15(d","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10723061","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120024494-IONS","pdf_url":null,"pub_time":1604419200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120024494/0001140361-20-024494-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120024494/brhc10016584_99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10016584_99-1.htm","type":"EX-99.1","id":"NTFILE9Rif3vrHh8BkFA7W","market":"us","size":453244},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120024494/brhc10016584_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10016584_8k.htm","type":"8-K","id":"NTFILEG3cz2XVcNCadyHqF","market":"us","size":25088},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120024494/image00001.jpg","primary":false,"translateUrl":null,"linkName":"image00001.jpg","type":"GRAPHIC","id":"NTFILE5RhDZKL4gvS6dHvv","market":"us","size":4803}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2020-11-04 00:00","pubTimestamp":1604419200,"title_zh":"8-K  - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10449402","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312520268022-IONS","pdf_url":null,"pub_time":1602518400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13D/A [Amend]  - General statement of acquisition of beneficial ownership","symbol":"IONS","title":"SC 13D/A [Amend]  - General statement of acquisition of beneficial ownership","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312520268022/0001193125-20-268022-index.htm","us_notice_code":"Form SC 13D/A","us_title_en":"SC 13D/A [Amend]  - General statement of acquisition of beneficial ownership","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"SC 13D/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520268022/d21546dsc13da.htm","primary":true,"translateUrl":null,"linkName":"d21546dsc13da.htm","type":"SC 13D/A","id":"NTFILE78ehvxp2bJrVEmj8","market":"us","size":33818}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2020-10-13 00:00","pubTimestamp":1602518400,"title_zh":"SC 13D/A [Amend]  - General statement of acquisition of beneficial ownership","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10449394","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312520268017-IONS","pdf_url":null,"pub_time":1602518400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312520268017/0001193125-20-268017-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.01: Completion of Acquisition or Disposition of Assets;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EX-99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520268017/d23018dex991.htm","primary":true,"translateUrl":null,"linkName":"d23018dex991.htm","type":"EX-99.1","id":"NTFILEG2mtTjgocxZAHnzQ","market":"us","size":9891},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520268017/d23018d8k.htm","primary":false,"translateUrl":null,"linkName":"d23018d8k.htm","type":"8-K","id":"NTFILE46YgMeRNt6KuAduz","market":"us","size":33679},{"description":"GRAPHIC","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520268017/g23018img1.jpg","primary":false,"translateUrl":null,"linkName":"g23018img1.jpg","type":"GRAPHIC","id":"NTFILEBXeL7rYmZvFZnTjF","market":"us","size":1774}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2020-10-13 00:00","pubTimestamp":1602518400,"title_zh":"8-K  - Current report","summary_en":"Item 2.01: Completion of Acquisition or Disposition of Assets;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10427499","market":"us","labels":[],"media":"sec.gov","original_id":"AN108887520000089-IONS","pdf_url":null,"pub_time":1601568000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000108887520000089/0001088875-20-000089-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000108887520000089/ionispharmaceuticals300920.txt","primary":true,"translateUrl":null,"linkName":"ionispharmaceuticals300920.txt","type":"SC 13G/A","id":"NTFILE8NuNoqFti6wTLqXJ","market":"us","size":9733}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2020-10-02 00:00","pubTimestamp":1601568000,"title_zh":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11100034","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312520253516-IONS","pdf_url":null,"pub_time":1600876800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"CORRESP [Cover] - Correspondence","symbol":"IONS","title":"CORRESP [Cover] - Correspondence","titleType":"Correspondence","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312520253516/0001193125-20-253516-index.htm","us_notice_code":"Form CORRESP","us_title_en":"CORRESP [Cover] - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520253516/filename1.htm","primary":true,"translateUrl":null,"linkName":"filename1.htm","type":"CORRESP","id":"NTFILE4qwHRGr1C2CRNF21","market":"us","size":34022}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Correspondence","pubTime":"2020-09-24 00:00","pubTimestamp":1600876800,"title_zh":"CORRESP [Cover] - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10322557","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312520235414-IONS","pdf_url":null,"pub_time":1598803200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13D/A [Amend]  - General statement of acquisition of beneficial ownership","symbol":"IONS","title":"SC 13D/A [Amend]  - General statement of acquisition of beneficial ownership","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235414/0001193125-20-235414-index.htm","us_notice_code":"Form SC 13D/A","us_title_en":"SC 13D/A [Amend]  - General statement of acquisition of beneficial ownership","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"SC 13D/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235414/d30784dsc13da.htm","primary":true,"translateUrl":null,"linkName":"d30784dsc13da.htm","type":"SC 13D/A","id":"NTFILE55hTuuiEgr9qwJ97","market":"us","size":40647}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2020-08-31 00:00","pubTimestamp":1598803200,"title_zh":"SC 13D/A [Amend]  - General statement of acquisition of beneficial ownership","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10322520","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312520235408-IONS","pdf_url":null,"pub_time":1598803200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/0001193125-20-235408-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EX-2.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/d75253dex21.htm","primary":true,"translateUrl":null,"linkName":"d75253dex21.htm","type":"EX-2.1","id":"NTFILEHRsQ5UBvjpLdygbx","market":"us","size":432502},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/d75253d8k.htm","primary":false,"translateUrl":null,"linkName":"d75253d8k.htm","type":"8-K","id":"NTFILEDcirVTobU5XKN9y6","market":"us","size":42020},{"description":"EX-99.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/d75253dex991.htm","primary":false,"translateUrl":null,"linkName":"d75253dex991.htm","type":"EX-99.1","id":"NTFILEAFPi3skPSrNybLMz","market":"us","size":22971},{"description":"XBRL TAXONOMY EXTENSION SCHEMA","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/ions-20200830.xsd","primary":false,"translateUrl":null,"linkName":"ions-20200830.xsd","type":"EX-101.SCH","id":"NTFILED5BihsgHi6PxgHPg","market":"us","size":3060},{"description":"XBRL TAXONOMY EXTENSION LABEL LINKBASE","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/ions-20200830_lab.xml","primary":false,"translateUrl":null,"linkName":"ions-20200830_lab.xml","type":"EX-101.LAB","id":"NTFILE9cGVC2aQouo7SnaX","market":"us","size":17373},{"description":"XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/ions-20200830_pre.xml","primary":false,"translateUrl":null,"linkName":"ions-20200830_pre.xml","type":"EX-101.PRE","id":"NTFILE57rjwEWWc48sNADB","market":"us","size":10946},{"description":"EXTRACTED XBRL INSTANCE DOCUMENT","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/d75253d8k_htm.xml","primary":false,"translateUrl":null,"linkName":"d75253d8k_htm.xml","type":"XML","id":"NTFILE3zcQDnVV3X8Jnu6M","market":"us","size":3272}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2020-08-31 00:00","pubTimestamp":1598803200,"title_zh":"8-K  - Current report","summary_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10240333","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120017841-IONS","pdf_url":null,"pub_time":1596988800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"S-8  - Securities to be offered to employees in employee benefit plans","symbol":"IONS","title":"S-8  - Securities to be offered to employees in employee benefit plans","titleType":"Employee Stock Ownership","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017841/0001140361-20-017841-index.htm","us_notice_code":"Form S-8","us_title_en":"S-8  - Securities to be offered to employees in employee benefit plans","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"S-8","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017841/nt10014191x2_s8.htm","primary":true,"translateUrl":null,"linkName":"nt10014191x2_s8.htm","type":"S-8","id":"NTFILEDHzBb94diRUBr5aU","market":"us","size":69196},{"description":"EXHIBIT 5.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017841/nt10014191x2_ex5-1.htm","primary":false,"translateUrl":null,"linkName":"nt10014191x2_ex5-1.htm","type":"EX-5.1","id":"NTFILE28URoTNPKUJeSJAS","market":"us","size":7187},{"description":"EXHIBIT 23.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017841/nt10014191x2_ex23-1.htm","primary":false,"translateUrl":null,"linkName":"nt10014191x2_ex23-1.htm","type":"EX-23.1","id":"NTFILE59j7PhAG138qsc26","market":"us","size":3122},{"description":"EXHIBIT 99.2","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017841/nt10014191x2_ex99-2.htm","primary":false,"translateUrl":null,"linkName":"nt10014191x2_ex99-2.htm","type":"EX-99.2","id":"NTFILEH2PJbDYCkcNXxQYN","market":"us","size":38021},{"description":"EXHIBIT 99.3","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017841/nt10014191x2_ex99-3.htm","primary":false,"translateUrl":null,"linkName":"nt10014191x2_ex99-3.htm","type":"EX-99.3","id":"NTFILE8cvmhEdjhf6WjWbP","market":"us","size":54883}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Employee Stock Ownership","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Employee Stock Ownership","pubTime":"2020-08-10 00:00","pubTimestamp":1596988800,"title_zh":"S-8  - Securities to be offered to employees in employee benefit plans","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10227766","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401520000115-IONS","pdf_url":null,"pub_time":1596556800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"10-Q  - Quarterly report [Sections 13 or 15(d)]","symbol":"IONS","title":"10-Q  - Quarterly report [Sections 13 or 15(d)]","titleType":"Quarterly Report","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/0000874015-20-000115-index.htm","us_notice_code":"Form 10-Q","us_title_en":"10-Q  - Quarterly report [Sections 13 or 15(d)]","is_important":0,"hasEarnInfos":true,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS INC 10-Q 6-30-2020","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/form10q.htm","primary":true,"translateUrl":null,"linkName":"form10q.htm","type":"10-Q","id":"NTFILE8nfv3HPdjjPkYQ4n","market":"us","size":2711698},{"description":"EXHIBIT 10.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ex10_1.htm","primary":false,"translateUrl":null,"linkName":"ex10_1.htm","type":"EX-10.1","id":"NTFILE8SSgCQRRPE6PnmHv","market":"us","size":6537},{"description":"EXHIBIT 10.2","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ex10_2.htm","primary":false,"translateUrl":null,"linkName":"ex10_2.htm","type":"EX-10.2","id":"NTFILE5GGEtcCEJc8Wmuok","market":"us","size":42752},{"description":"EXHIBIT 31.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ex31_1.htm","primary":false,"translateUrl":null,"linkName":"ex31_1.htm","type":"EX-31.1","id":"NTFILE4YhCJHvKGE2xx1YY","market":"us","size":13545},{"description":"EXHIBIT 31.2","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ex31_2.htm","primary":false,"translateUrl":null,"linkName":"ex31_2.htm","type":"EX-31.2","id":"NTFILE7jAkVtkkzCa3yXo3","market":"us","size":13394},{"description":"EXHIBIT 32.1","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ex32_1.htm","primary":false,"translateUrl":null,"linkName":"ex32_1.htm","type":"EX-32.1","id":"NTFILEFChMaWooo1Rv21K1","market":"us","size":6948},{"description":"XBRL TAXONOMY EXTENSION SCHEMA","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ions-20200630.xsd","primary":false,"translateUrl":null,"linkName":"ions-20200630.xsd","type":"EX-101.SCH","id":"NTFILE2woyNS3z7cueYr54","market":"us","size":46977},{"description":"XBRL TAXONOMY EXTENSION CALCULATION LINKBASE","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ions-20200630_cal.xml","primary":false,"translateUrl":null,"linkName":"ions-20200630_cal.xml","type":"EX-101.CAL","id":"NTFILEFFAfyJcAXhyE6Ps1","market":"us","size":68911},{"description":"XBRL TAXONOMY EXTENSION DEFINITION LINKBASE","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ions-20200630_def.xml","primary":false,"translateUrl":null,"linkName":"ions-20200630_def.xml","type":"EX-101.DEF","id":"NTFILEFaiU3TpXERUqqosr","market":"us","size":301998},{"description":"XBRL TAXONOMY EXTENSION LABEL LINKBASE","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ions-20200630_lab.xml","primary":false,"translateUrl":null,"linkName":"ions-20200630_lab.xml","type":"EX-101.LAB","id":"NTFILEGvUX5dPjbYsdvAzv","market":"us","size":717001},{"description":"XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ions-20200630_pre.xml","primary":false,"translateUrl":null,"linkName":"ions-20200630_pre.xml","type":"EX-101.PRE","id":"NTFILEEyym6oLBaDq9ZZW4","market":"us","size":413462},{"description":"EXTRACTED XBRL INSTANCE DOCUMENT","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/form10q_htm.xml","primary":false,"translateUrl":null,"linkName":"form10q_htm.xml","type":"XML","id":"NTFILEEwotegDtYyZS7edn","market":"us","size":2334808}],"type_name":"Financial Report","type_name_en":"Financial Report","titleTypeEn":"Quarterly Report","us_type":"财务报告","us_type_zh":"财务报告","earn_infos":[{"id":21334,"name":"CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/R2.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":21335,"name":"CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/R3.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":21336,"name":"CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/R4.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":21337,"name":"CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/R5.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":21338,"name":"CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/R6.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":21339,"name":"CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited)","name_zh":"简明合并现金流量表（未经审计）","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/R7.htm","cdn_url":"https://static.tigerbbs.com/0e87fc1d91f2aa9b812d801ba4836993","translation_url":"https://static.tigerbbs.com/e5aead93e65fe72566bec65d47b7e36f","translate_status":1}],"event_type":"important_notice","event_name":"Quarterly Report","pubTime":"2020-08-05 00:00","pubTimestamp":1596556800,"title_zh":"10-Q  - Quarterly report [Sections 13 or 15(d","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10225960","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120017532-IONS","pdf_url":null,"pub_time":1596556800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/0001140361-20-017532-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/brhc10014107_ex99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10014107_ex99-1.htm","type":"EX-99.1","id":"NTFILE7MYikNDzDwRq7uGc","market":"us","size":422287},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/brhc10014107_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10014107_8k.htm","type":"8-K","id":"NTFILEFcDyqksXELMyEPS1","market":"us","size":25381},{"description":"XBRL TAXONOMY EXTENSION SCHEMA","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/ions-20200805.xsd","primary":false,"translateUrl":null,"linkName":"ions-20200805.xsd","type":"EX-101.SCH","id":"NTFILE2nnoYcWVeDpZ9fHm","market":"us","size":4198},{"description":"XBRL TAXONOMY EXTENSION LABEL LINKBASE","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/ions-20200805_lab.xml","primary":false,"translateUrl":null,"linkName":"ions-20200805_lab.xml","type":"EX-101.LAB","id":"NTFILEEb3wtjYaF9c3JFti","market":"us","size":22718},{"description":"XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/ions-20200805_pre.xml","primary":false,"translateUrl":null,"linkName":"ions-20200805_pre.xml","type":"EX-101.PRE","id":"NTFILEBYzzXkCW8EvpP4Qg","market":"us","size":16218},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/image0.jpg","primary":false,"translateUrl":null,"linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILEEFm16q1PJu9QDzwr","market":"us","size":11774},{"description":"EXTRACTED XBRL INSTANCE DOCUMENT","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/brhc10014107_8k_htm.xml","primary":false,"translateUrl":null,"linkName":"brhc10014107_8k_htm.xml","type":"XML","id":"NTFILE4sRmj1GQRshkQTxF","market":"us","size":4078}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2020-08-05 00:00","pubTimestamp":1596556800,"title_zh":"8-K  - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0}],"pageSize":20,"totalPage":22,"pageCount":17,"totalSize":426,"code":"91000000","status":"200"}]}}