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Karyopharm Therapeutics

1.61

-0.0100-0.62%

Post-market: 1.60-0.0096-0.60%19:59 EDT

Volume:6.74M

Turnover:9.67M

Market Cap:36.49M

PE:-0.12

High:1.61

Open:1.50

Low:1.24

Close:1.62

52wk High:10.99

52wk Low:1.24

Shares:22.66M

Float Shares:15.77M

Volume Ratio:8.47

T/O Rate:42.71%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-13.0816

EPS(LYR):-17.9300

ROE:-891.05%

ROA:-47.61%

PB:-0.11

PE(LYR):-0.09

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Overview Company News Filings

Karyopharm Plans to Submit Snda for Selinexor Plus Ruxolitinib in Myelofibrosis Under Accelerated Approval Pathway

THOMSON REUTERS

Karyopharm Therapeutics - to Request Priority Review with Snda Submission for Selinexor Plus Ruxolitinib

THOMSON REUTERS

Karyopharm Plans August sNDA Filing Seeking FDA Priority Review for Selinexor-ruxolitinib in Myelofibrosis

Karyopharm Says Phase 3 Selinexor Maintenance Trial in Endometrial Cancer Misses PFS Endpoint

Karyopharm Therapeutics - no New Safety Signals Observed for Selinexor in Phase 3 Trial

THOMSON REUTERS

Karyopharm Therapeutics - to Reduce Planned Investment in Endometrial Cancer Program

THOMSON REUTERS

Karyopharm Therapeutics - Phase 3 Xport-Ec-042 Trial Does not Meet Primary Endpoint

THOMSON REUTERS

NASDAQ Trade Halt Halt News Pending at 04:01 Pm

Karyopharm sinks after revealing executive cash retention program

RBC says Karyopharm weakness after compensation plan a buying opportunity

Stocks to Wtach: Karyopharm Therapeutics, Mkdwell, Advanced Biomed

Karyopharm Therapeutics Slides on Disclosure of Cash-retention Program for Executives

Karyopharm Grants 1,649 Rsus to Four New Hires Under Inducement Plan

Karyopharm Therapeutics Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)

THOMSON REUTERS

Analysts Are Bullish on These Healthcare Stocks: BioAge Labs, Inc. (BIOA), Karyopharm Therapeutics (KPTI)

Karyopharm posts Phase 3 SENTRY trial presentation on selinexor plus ruxolitinib in myelofibrosis

Karyopharm posts endometrial cancer treatment landscape presentation

Karyopharm joins Cantor-hosted webcast featuring endometrial cancer KOL Robert Coleman

Karyopharm says Phase 3 SENTRY trial selected for presentation at EHA 2026

Karyopharm to Report Data From Phase 3 Trial of Selinexor Plus Ruxolitinib in Myelofibrosis

MT Newswires Live

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program","url":"https://stock-news.laohu8.com/highlight/detail?id=2653024811","media":"TIPRANKS","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2653024811?lang=en_us&edition=fundamental","pubTime":"2026-07-21 02:35","pubTimestamp":1784572522,"startTime":"0","endTime":"0","summary":"Shares of Karyopharm (KPTI) are trading lower after the company on Friday night disclosed that its board implemented a retention program for certai...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/karyopharm-sinks-after-revealing-executive-cash-retention-program-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/karyopharm-sinks-after-revealing-executive-cash-retention-program-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2653248111","title":"RBC says Karyopharm weakness after compensation plan a buying opportunity","url":"https://stock-news.laohu8.com/highlight/detail?id=2653248111","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2653248111?lang=en_us&edition=fundamental","pubTime":"2026-07-21 02:35","pubTimestamp":1784572516,"startTime":"0","endTime":"0","summary":"RBC Capital notes Karyopharm (KPTI) shares are down 28% today after the company updated their incentive compensation plan on Friday after the close...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/rbc-says-karyopharm-weakness-after-compensation-plan-a-buying-opportunity-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/rbc-says-karyopharm-weakness-after-compensation-plan-a-buying-opportunity-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU0029864427.USD","BK4139","KPTI","GSIB","LU0708994859.HKD","BK4207","LU1267930573.SGD","LU0128525929.USD","LU0310800379.SGD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2652233435","title":"Stocks to Wtach: Karyopharm Therapeutics, Mkdwell, Advanced Biomed","url":"https://stock-news.laohu8.com/highlight/detail?id=2652233435","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2652233435?lang=en_us&edition=fundamental","pubTime":"2026-07-18 06:31","pubTimestamp":1784327460,"startTime":"0","endTime":"0","summary":"Karyopharm Therapeutics said its CEO will receive more than $1.7 million under a new cash retention program for top executives. Shares fell 21% to $7.50 in after-hours trading on Friday.MKDWELL agreed to purchase the parent company of smart-home and Internet-of-Things products developer Landvision Technology for an aggregate consideration of $240 million. The stock was up 6% to $11.83 after the bell.Advanced Biomed terminated a purchase agreement which gave it the right to issue and sell $25 million worth of shares to an investor. Shares were up 35% to $6.80.Write to Elias Schisgall at elias.schisgall@wsj.com Dow Jones NewswiresJuly 17, 2026 18:31 ET Copyright  2026 Dow Jones & Company, Inc.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI","MKDW","ADVB","BK4198","BK4124","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2652233925","title":"Karyopharm Therapeutics Slides on Disclosure of Cash-retention Program for Executives","url":"https://stock-news.laohu8.com/highlight/detail?id=2652233925","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2652233925?lang=en_us&edition=fundamental","pubTime":"2026-07-18 06:14","pubTimestamp":1784326440,"startTime":"0","endTime":"0","summary":"Shares of Karyopharm Therapeutics fell after the company launched a cash-retention program for executives.The stock slipped 21%, to $7.50, in after-hours trading Friday, after closing up 1.4%, at $9.51. At close, the stock had risen 29% year-to-date.Under the program, Chief Executive Officer Richard Paulson will receive a cash retention award of more than $1.7 million, the company disclosed in a Friday filing with the Securities and Exchange Commission.Chief Medical Officer and Head of Research Reshma Rangwala will receive $725,000, Chief Development Officer Stuart Poulton will get $640,000, and Chief Financial Officer Lori Macomber will get $625,000.\"The purpose of the 2026 Leadership Cash Retention Program is to incentivize retention of key employees during a period in which the Company is expecting several meaningful catalysts requiring the continued experience and expertise of the designated employees,\" the company said in its filing.Write to Elias Schisgall at elias.schisgall@wsj.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2648525264","title":"Karyopharm Grants 1,649 Rsus to Four New Hires Under Inducement Plan","url":"https://stock-news.laohu8.com/highlight/detail?id=2648525264","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2648525264?lang=en_us&edition=fundamental","pubTime":"2026-07-02 04:06","pubTimestamp":1782936384,"startTime":"0","endTime":"0","summary":"Karyopharm grants 1,649 RSUs to four new hires under inducement planKaryopharm Therapeutics granted 1,649 restricted stock units to four newly hired employees under its 2022 Inducement Stock Incentive","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260701:nNDLbhZgvy:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2648352547","title":"Karyopharm Therapeutics Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)","url":"https://stock-news.laohu8.com/highlight/detail?id=2648352547","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2648352547?lang=en_us&edition=fundamental","pubTime":"2026-07-02 04:05","pubTimestamp":1782936300,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260701:nTUA75RZN2:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2644741614","title":"Analysts Are Bullish on These Healthcare Stocks: BioAge Labs, Inc. (BIOA), Karyopharm Therapeutics (KPTI)","url":"https://stock-news.laohu8.com/highlight/detail?id=2644741614","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2644741614?lang=en_us&edition=fundamental","pubTime":"2026-06-17 21:30","pubTimestamp":1781703053,"startTime":"0","endTime":"0","summary":"There’s a lot to be optimistic about in the Healthcare sector as 3 analysts just weighed in on BioAge Labs, Inc. (BIOA), Karyopharm Therapeutics (K...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/analysts-are-bullish-on-these-healthcare-stocks-bioage-labs-inc-bioa-karyopharm-therapeutics-kpti-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/analysts-are-bullish-on-these-healthcare-stocks-bioage-labs-inc-bioa-karyopharm-therapeutics-kpti-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BIOA","BK4139","KPTI","BK4007"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2643246520","title":"Karyopharm posts Phase 3 SENTRY trial presentation on selinexor plus ruxolitinib in myelofibrosis","url":"https://stock-news.laohu8.com/highlight/detail?id=2643246520","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2643246520?lang=en_us&edition=fundamental","pubTime":"2026-06-14 16:14","pubTimestamp":1781424853,"startTime":"0","endTime":"0","summary":"Karyopharm published Phase 3 SENTRY trial results evaluating selinexor with ruxolitinib in JAK inhibitor-nave myelofibrosis.Combination delivered rapid, deeper, sustained spleen volume reduction versus ruxolitinib alone, with consistent effects across subgroups.Symptom improvement was similar between arms, with meaningful reductions from baseline.Overall survival signal reported; spleen volume reduction linked with improved survival.Safety described as manageable, consistent with known profiles of both drugs.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Karyopharm Therapeutics Inc. published the original content used to generate this news brief on June 14, 2026, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260614:nNDL4sLjbX:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2642433662","title":"Karyopharm posts endometrial cancer treatment landscape presentation","url":"https://stock-news.laohu8.com/highlight/detail?id=2642433662","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2642433662?lang=en_us&edition=fundamental","pubTime":"2026-06-09 00:04","pubTimestamp":1780934643,"startTime":"0","endTime":"0","summary":"Karyopharm published an endometrial cancer treatment landscape update centered on selinexor as an oral XPO1 inhibitor in maintenance therapy.Highlights SIENDO Phase 3 exploratory TP53 wild-type subgroup: median PFS 13.7 months vs 3.7 months; HR 0.41; P=0.002.Reports longer-term follow-up in TP53 wild-type: median PFS 28.4 months vs 5.2 months; HR 0.44; data cutoff April 1, 2024.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Karyopharm Therapeutics Inc. published the original content used to generate this news brief on June 08, 2026, and is solely responsible for the information contained therein.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260608:nNDL8Gshr7:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640918166","title":"Karyopharm joins Cantor-hosted webcast featuring endometrial cancer KOL Robert Coleman","url":"https://stock-news.laohu8.com/highlight/detail?id=2640918166","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2640918166?lang=en_us&edition=fundamental","pubTime":"2026-06-04 04:15","pubTimestamp":1780517756,"startTime":"0","endTime":"0","summary":"Karyopharm will join a Cantor-hosted virtual fireside chat on June 8, 2026 at 12:00 p.m. ET.Discussion will feature senior management alongside Robert Coleman, principal investigator of the Phase 3 XPORT-EC-042 endometrial cancer trial.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260603:nNDL2kKBBk:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640494268","title":"Karyopharm says Phase 3 SENTRY trial selected for presentation at EHA 2026","url":"https://stock-news.laohu8.com/highlight/detail?id=2640494268","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2640494268?lang=en_us&edition=fundamental","pubTime":"2026-06-03 00:02","pubTimestamp":1780416139,"startTime":"0","endTime":"0","summary":"Karyopharm (KPTI) Therapeutics announced that its late-breaking abstract was accepted for an oral presentation at the 2026 European Hematology Asso...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/karyopharm-says-phase-3-sentry-trial-selected-for-presentation-at-eha-2026-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/karyopharm-says-phase-3-sentry-trial-selected-for-presentation-at-eha-2026-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["KPTI","BK4139","EPV"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640194481","title":"Karyopharm to Report Data From Phase 3 Trial of Selinexor Plus Ruxolitinib in Myelofibrosis","url":"https://stock-news.laohu8.com/highlight/detail?id=2640194481","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2640194481?lang=en_us&edition=fundamental","pubTime":"2026-06-02 23:21","pubTimestamp":1780413677,"startTime":"0","endTime":"0","summary":"Karyopharm Therapeutics  said Tuesday that a late-breaking abstract from its phase 3 trial of selinexor combined with ruxolitinib in myelofibrosis was accepted for an oral presentation at the 2026 European Hematology Association Congress in mid-June.The company said new data will highlight a post-hoc analysis of 24 patients from phase 1 of the trial, which indicates that achieving a spleen volume reduction of 35% or more may predict overall survival, consistent with a similar analysis from the phase 3 trial.Shares of Karyopharm Therapeutics were down more than 8% in Tuesday trading.Price: 8.99, Change: -0.84, Percent Change: -8.50","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4139","KPTI"],"isVideo":false,"video":null,"gpt_icon":0}],"pageSize":20,"totalPage":6,"pageCount":3,"totalSize":113,"code":"91000000","status":"200"}]}}