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see...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/structure-weakness-disconnected-from-underlying-data-says-jefferies-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/structure-weakness-disconnected-from-underlying-data-says-jefferies-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["APXH","BME","IBRN","GNOM","SBIO","IBBQ","GPCR","IBBJ","IBB","RSPH","XPH","CURE","MEDI","SURI","GNMX","JDOC","BBH","FHLC","MDTX","MEDX","BIB","MNTL","SYNB","PBE","PJP","JHMH","LFSC","FBT","PSCH","PTH","HYLG","LLYX","GDOC","WDNA","NVIB","MRNY","PSIL","HRTS","PBPH","TBXU","PINK","FTXH","CANC","IEIH","GSKH","CNCR","FXH","AZNH","IDNA","BBP"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2666374278","title":"Amgen Stock Poised for Worst Day in More than Two Decades","url":"https://stock-news.laohu8.com/highlight/detail?id=2666374278","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2666374278?lang=en_us&edition=fundamental","pubTime":"2026-09-09 02:20","pubTimestamp":1788891600,"startTime":"0","endTime":"0","summary":"Shares of Amgen were recently down more than 9%, putting the biotechnology company on pace for its largest decrease since October 2000.The decline came after Novartis announced a failure of its heart 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Pharmaceuticals Inc Stock (VRTX) Moved Down by 3.06% on Sep 8: What Signal Does It Send?","url":"https://stock-news.laohu8.com/highlight/detail?id=2666372878","media":"TradingKey","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2666372878?lang=en_us&edition=fundamental","pubTime":"2026-09-09 02:15","pubTimestamp":1788891334,"startTime":"0","endTime":"0","summary":"• Vertex shares faced volatility and profit-taking after rallying near their 52-week high.\n• The Crinetics acquisition integration will not be non-GAAP accretive until 2029.\n• Technical indicators show a neutral MACD, neutral RSI, and oversold Williams 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Midday Decliners","url":"https://stock-news.laohu8.com/highlight/detail?id=2666637499","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2666637499?lang=en_us&edition=fundamental","pubTime":"2026-09-09 01:57","pubTimestamp":1788890247,"startTime":"0","endTime":"0","summary":"Sigma Lithium's (SGML) mining and industrial operations remain unaffected by a preliminary judicial ruling that allegedly suspends its environmental licenses, the company said Monday.Shares sank more 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Pharma Down Nearly 6%, on Pace for Largest Percent Decrease Since March 2025","url":"https://stock-news.laohu8.com/highlight/detail?id=2666372374","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2666372374?lang=en_us&edition=fundamental","pubTime":"2026-09-09 01:26","pubTimestamp":1788888360,"startTime":"0","endTime":"0","summary":"Royalty Pharma Plc Class A  is currently at $60.20, down $3.76 or 5.88%--Would be lowest close since Aug. 18, 2026, when it closed at $59.69--On pace for largest percent decrease since March 26, 2025, when it fell 6.52%--Snaps a five-day winning streak--Down 1.97% month-to-date--Up 55.8% year-to-date--Down 5.88% from its all-time closing high of $63.96 on Sept. 4, 2026--Up 64.93% from 52 weeks ago , when it closed at $36.50--Down 5.88% from its 52-week closing high of $63.96 on Sept. 4, 2026--Up 72.49% from its 52-week closing low of $34.90 on Sept. 25, 2025--Traded as low as $58.63; lowest intraday level since Aug. 17, 2026, when it hit $58.18--Down 8.33% at today's intraday low; largest intraday percent decrease since June 19, 2020, when it fell as much as 8.53%All data as of 1:22:25 PM ETSource: Dow Jones Market Data, FactSet","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["PBE","IHE","BK4007","RPRX"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2666710603","title":"Amgen's Olpasiran May Still Show Heart-Risk Reduction Despite Novartis Miss, UBS Says","url":"https://stock-news.laohu8.com/highlight/detail?id=2666710603","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2666710603?lang=en_us&edition=fundamental","pubTime":"2026-09-09 01:09","pubTimestamp":1788887360,"startTime":"0","endTime":"0","summary":"Amgen's  experimental heart drug olpasiran may still show a meaningful reduction in major cardiovascular events, even after Novartis'  competing drug failed in a large study, UBS Securities said Monday in a report.Novartis' pelacarsen trial came up short overall, though UBS' analysis suggests the drug might have shown a modest benefit of 7% to 11% reduction in heart-attack-and-stroke risk among patients with very high levels of lipoprotein, a cholesterol-like particle linked to heart disease, the report said.Amgen's study focuses on an even higher-risk group, and olpasiran lowers lipoprotein to a greater degree than pelacarsen, UBS said. Amgen's trial also uses a different primary endpoint that excludes stroke, and taken together, these factors may help turn a small numerical benefit into a statistically significant result, potentially around a 15% reduction in major cardiovascular events, the report said.UBS maintained its buy rating on Amgen stock and its $440 price target.Amgen shar","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4007","IE0002141913.USD","LU2112291526.USD","BK4585","BK4534","SG9999001440.SGD","BIB","LU0109394709.USD","LU0320765992.SGD","BK4533","LU0211331839.USD","BBH","LU2089984988.USD","LU0122379950.USD","LU2242652126.USD","LU2468319806.SGD","IE00B2B36J28.USD","IBBQ","IBB","LU1983299246.USD","IE0009355771.USD","BK4581","AMGN","PJP","LU0289739699.SGD","IE00BFTCPJ56.SGD","BK4532","PBE","LU0070302665.USD","LU0868494617.USD","LU1061106388.HKD","LU2242646821.SGD","PPH","IE00BJJMRZ35.SGD","NVS","IE00BJT1NW94.SGD","BK4599","LU1023059063.AUD","BK4566","TBXU","LU0889565916.HKD","LU0208291251.USD","LU1057294990.SGD","IE00B4R5TH58.HKD","BK4588","LU0058720904.USD","MEDX","BK4578","BK4139","LU1571399168.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2666737149","title":"Royalty Pharma Falls After Novartis' Cholesterol Drug Fails in Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2666737149","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2666737149?lang=en_us&edition=fundamental","pubTime":"2026-09-09 00:40","pubTimestamp":1788885632,"startTime":"0","endTime":"0","summary":"BUZZ-Royalty Pharma falls after Novartis' cholesterol drug fails in study** Shares of Royalty PharmaRPRX.Ofall 6% to $60.14 in afternoon trade** RPRX buys royalties of future drugs from academic labs and biotechs** Swiss drugmaker Novartis'NOVN.Scholesterol drug pelacarsenfailsin a closely watched study** RPRX says its $500 million funding agreement with NOVN's partner IonisIONS.Owas structured to limit risk with stable and predictable royalties in another drug Spinraza and potential gains from pelacarsen** RPRX expects to recoup its total investment and earn a modest positive return despite pelacarsen's failure**  \"We had previously estimated combined 2032 end-market sales of $1.6B  and royalties of $80MM . A missed opportunity, but the growth outlook is little changed\" - Royalty Pharma** RPRX reiterates \"its 2030 Portfolio Receipts target of $4.7 billion or more\"** Including session's move, stock up 54.7% YTD","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260908:nL4N4501D1:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LU1057294990.SGD","IE00BJJMRZ35.SGD","LU0320765992.SGD","BIB","LU0868494617.USD","LU1571399168.USD","BBH","BK4585","LU0109394709.USD","IE00B4R5TH58.HKD","LU0058720904.USD","IE0009355771.USD","BK4534","BK4533","LU2242652126.USD","PJP","BK4139","BK4581","LU1983299246.USD","BK4599","IE00BFTCPJ56.SGD","IHE","SG9999001440.SGD","LU2242646821.SGD","IE00BJT1NW94.SGD","LU0289739699.SGD","LU2112291526.USD","TBXU","AMGN","IE0002141913.USD","RPRX","LU1061106388.HKD","LU1023059063.AUD","PBE","IONS","IBB","LU0889565916.HKD","IBBQ","BK4566","BK4588","IE00B2B36J28.USD","LU0122379950.USD","BK4007","LU2468319806.SGD","LU2089984988.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2666711753","title":"Amgen Pulls Dow Industrials Lower; Oil Jumps on Houthi Strikes in Saudi Arabia","url":"https://stock-news.laohu8.com/highlight/detail?id=2666711753","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2666711753?lang=en_us&edition=fundamental","pubTime":"2026-09-09 00:29","pubTimestamp":1788884940,"startTime":"0","endTime":"0","summary":"U.S. stock indexes fell to start the week as rising oil prices added to investor anxiety.The Dow industrials led declines, falling about 550 points, or 1%. The S&P 500 and Nasdaq composite were down 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Top and Bottom Performing Stocks at About 11:01 A.m. 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Says Phase 3 Study Meets Primary Endpoint in Small Cell Lung Cancer","url":"https://stock-news.laohu8.com/highlight/detail?id=2665376182","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665376182?lang=en_us&edition=fundamental","pubTime":"2026-09-08 22:26","pubTimestamp":1788877568,"startTime":"0","endTime":"0","summary":"Amgen  said Tuesday its phase 3 DeLLphi-305 study met its primary endpoint, with Imdelltra in combination with AstraZeneca's  Imfinzi showing a statistically significant and clinically meaningful improvement in overall survival in patients with extensive-stage small cell lung cancer.The study evaluated the combination as first-line maintenance treatment for patients with extensive-stage small cell lung cancer whose disease had not progressed after initial treatment, Amgen said. The combination also improved progression-free survival and objective response rate, the company said.The safety profile was consistent with the known profiles of the individual medicines, with no new or unexpected safety signals identified, the company said, adding that it plans to present detailed results at an upcoming medical congress and share the data with regulatory authorities.Price: 402.00, Change: -35.23, Percent Change: 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Inc Stock (AMGN) Moved Down by 8.33% on Sep 8: A Full Analysis","url":"https://stock-news.laohu8.com/highlight/detail?id=2665376204","media":"TradingKey","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665376204?lang=en_us&edition=fundamental","pubTime":"2026-09-08 22:15","pubTimestamp":1788876930,"startTime":"0","endTime":"0","summary":"• Novartis trial failure for pelacarsen increased clinical uncertainty for Amgen's competing olpasiran.\n• BMO Capital downgraded Amgen from Outperform to Market Perform amid valuation concerns.\n• Technical indicators show Amgen's RSI at 40.256 and Williams %R at 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Stocks on the MOVE-Sigma Lithium, Shake Shack, Novartis","url":"https://stock-news.laohu8.com/highlight/detail?id=2665752763","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665752763?lang=en_us&edition=fundamental","pubTime":"2026-09-08 21:57","pubTimestamp":1788875845,"startTime":"0","endTime":"0","summary":"BUZZ-U.S. STOCKS ON THE MOVE-Sigma Lithium, Shake Shack, NovartisSeptember 8 (Reuters)-Wall Street's main indexes were mixed at open on Tuesday as fresh hostilities in the Middle East pushed oil 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Drops 438 Points on Losses for Amgen, Salesforce Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2665754593","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665754593?lang=en_us&edition=fundamental","pubTime":"2026-09-08 21:45","pubTimestamp":1788875100,"startTime":"0","endTime":"0","summary":"DJ Dow Drops 438 Points On Losses For Amgen, Salesforce SharesThis article was automatically generated by MarketWatch using technology from Automated Insights.The Dow Jones Industrial Average is declining Tuesday morning with shares of Amgen and Salesforce seeing the biggest declines for the blue-chip average.Shares of Amgen  and Salesforce  are contributing to the index's intraday decline, as the Dow  was most recently trading 438 points, or 0.8%, lower.Amgen's shares have declined $30.47, or 7.0%, while those of Salesforce have fallen $11.09, or 4.3%, combining for a roughly 247-point drag on the Dow.Also contributing significantly to the decline are Johnson & Johnson , IBM , and Microsoft .A $1 move in any of the Dow's 30 components equates to a 5.94-point swing.Data source: Dow Jones Market Data, FactSet. Data compiled September 8, 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Down Nearly 7%, on Pace for Largest Percent Decrease Since March 2020","url":"https://stock-news.laohu8.com/highlight/detail?id=2665375160","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665375160?lang=en_us&edition=fundamental","pubTime":"2026-09-08 21:41","pubTimestamp":1788874860,"startTime":"0","endTime":"0","summary":"Amgen Inc.  is currently at $403.61, down $33.62 or 7.69%--Would be lowest close since Aug. 4, 2026, when it closed at $390.02--On pace for largest percent decrease since March 12, 2020, when it fell 8.26%--Currently down two consecutive days; down 9.12% over this period--Worst two day stretch since the two days ending March 12, 2020, when it fell 11.88%--Down 6.11% month-to-date--Up 23.31% year-to-date--Down 9.12% from its all-time closing high of $444.12 on Sept. 3, 2026--Up 44.16% from 52 weeks ago , when it closed at $279.97--Down 9.12% from its 52-week closing high of $444.12 on Sept. 3, 2026--Up 48.83% from its 52-week closing low of $271.18 on Sept. 25, 2025--Traded as low as $399.68; lowest intraday level since Aug. 5, 2026, when it hit $391.00--Down 8.59% at today's intraday low; largest intraday percent decrease since Nov. 26, 2024, when it fell as much as 12.31%--Worst performer in the S&P 500 today--Worst performer in the Nasdaq 100 todayAll data as of 9:38:16 AM ETSource: 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