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SPYRE THERAPEUTICS INC

90.60

+1.892.13%

Post-market: 90.600.00000.00%19:30 EDT

Volume:886.06K

Turnover:79.81M

Market Cap:7.99B

PE:-45.08

High:91.41

Open:90.00

Low:87.89

Close:88.71

52wk High:110.18

52wk Low:14.51

Shares:88.17M

Float Shares:80.98M

Volume Ratio:0.88

T/O Rate:1.09%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.0100

EPS(LYR):-1.9755

ROE:-22.98%

ROA:-19.81%

PB:8.37

PE(LYR):-45.86

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Overview Company News Filings

Analysts Offer Insights on Healthcare Companies: Solventum Corporation (SOLV), Argenx Se (ARGX) and Spyre Therapeutics (SYRE)

Spyre Therapeutics Reports Phase 2 Skyway RA Data for Spy072 Shows Statistically Significant Benefit vs Placebo

Spyre Therapeutics Shares Down 12.4% Premarket After Co's Experimental Drug Fails to Meet Threshold for Monotherapy Development in Rheumatoid Arthritis

THOMSON REUTERS

Spyre Therapeutics Inc : Btig Cuts Target Price to $121 from $132

THOMSON REUTERS

Stocks to Watch: Intuit, Spyre Therapeutics, Zoom Communications, nCino

Spyre Therapeutics Stock (SYRE) Tumbles 14% in After-Hours – Here’s What Spooked Investors

Spyre Therapeutics Won't Prioritize Rheumatoid Arthritis Monotherapy After Trial

Spyre Therapeutics announces results from RA sub-study of SKYWAY basket trial

Spyre Therapeutics Announces Topline Results from the Rheumatoid Arthritis Sub-Study of the Skyway Phase 2 Trial of Spy072

THOMSON REUTERS

Spyre Therapeutics - Spy072 Well Tolerated with Adverse Event Rates Comparable to Placebo

THOMSON REUTERS

Spyre Therapeutics Inc: Spy072 in Combination with Il17-a/F in Hidradenitis Suppurativa (Hs) in Late 2027 or Early 2028

THOMSON REUTERS

Spyre Therapeutics - Topline Data for Spy072 in Psa and Axspa Expected Q4 2026

THOMSON REUTERS

Spyre Therapeutics Inc - Magnitude of Effect Did not Meet Company's Target to Prioritize Monotherapy Development of Spy072 in Rheumatoid Arthritis

THOMSON REUTERS

Spyre Therapeutics - Spy072 Shows Statistically Significant Benefits Versus Placebo on Multiple Endpoints

THOMSON REUTERS

Spyre Therapeutics Announces Topline Results from the Rheumatoid Arthritis Sub-study of the SKYWAY Phase 2 Trial of SPY072

Is Spyre Therapeutics (SYRE) Fully Priced After Its SPY772 Program And SKYLIGHT Trial Launch?

Simply Wall St.

LifeSci Capital Reaffirms Their Buy Rating on Spyre Therapeutics (SYRE)

Analysts Offer Insights on Healthcare Companies: TransMedics Group (TMDX), Spyre Therapeutics (SYRE) and COMPASS Pathways (CMPS)

Wedbush Keeps Their Buy Rating on Spyre Therapeutics (SYRE)

Analysts Offer Insights on Healthcare Companies: Spyre Therapeutics (SYRE), Stereotaxis (STXS) and Tvardi Therapeutics (TVRD)

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The company may also accept short-term trade-offs in its business as it looks to boost TurboTax customers, its CFO told The Wall Street Journal. Shares fell 9.8% to $322.57 in after-hours trading on Tuesday.Spyre Therapeutics said it will not prioritize developing one of its drug candidates as a monotherapy for rheumatoid arthritis after results from a trial missed its internal targets. The stock slid 11% to $95.09 after the bell.Zoom Communications issued guidance for third-quarter adjusted earnings per share that missed Wall Street expectations. Shares were down 3.9% at $97.00.NCino projected third-quarter revenue in a range with a midpoint below analyst expectations. 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The low dose demonstrated a statistically significant benefit on the study's primary endpoint, the company added.But the magnitude of the results missed the company's targets, it said.\"The results provide proof-of-mechanism for TL1A in RA and support its potential in other autoimmune diseases and as a combination component, but did not meet the Company's internal bar to prioritize advancement of SPY072 in RA,\" the company said. SPY072 is designed to inhi","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4539","BK4139","LENZ","SYRE","LFSC","BK4007"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2662754700","title":"Spyre Therapeutics announces results from RA sub-study of SKYWAY basket trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2662754700","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2662754700?lang=en_us&edition=fundamental","pubTime":"2026-08-26 04:05","pubTimestamp":1787688312,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics (SYRE) announced results from the RA sub-study of its Phase 2 SKYWAY basket trial evaluating SPY072 in rheumatic diseases. Both ...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/spyre-therapeutics-announces-results-from-ra-sub-study-of-skyway-basket-trial-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/spyre-therapeutics-announces-results-from-ra-sub-study-of-skyway-basket-trial-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SYRE","BK4539","BK4007","LENZ","LFSC","RA","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2662981754","title":"Spyre Therapeutics Announces Topline Results from the Rheumatoid Arthritis Sub-Study of the Skyway Phase 2 Trial of Spy072","url":"https://stock-news.laohu8.com/highlight/detail?id=2662981754","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2662981754?lang=en_us&edition=fundamental","pubTime":"2026-08-26 04:01","pubTimestamp":1787688060,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260825:nTUA3HCVK8:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","SYRE","LFSC"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2662754989","title":"Spyre Therapeutics - 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Spy072 Shows Statistically Significant Benefits Versus Placebo on Multiple Endpoints","url":"https://stock-news.laohu8.com/highlight/detail?id=2662475498","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2662475498?lang=en_us&edition=fundamental","pubTime":"2026-08-26 04:01","pubTimestamp":1787688060,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260825:nTUA3HCVK8:3","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","SYRE","LFSC"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2662175441","title":"Spyre Therapeutics Announces Topline Results from the Rheumatoid Arthritis Sub-study of the SKYWAY Phase 2 Trial of SPY072","url":"https://stock-news.laohu8.com/highlight/detail?id=2662175441","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2662175441?lang=en_us&edition=fundamental","pubTime":"2026-08-26 04:01","pubTimestamp":1787688060,"startTime":"0","endTime":"0","summary":"Both doses of SPY072 demonstrated statistically significant benefits compared to placebo on one or more of the primary (change from baseline in DAS28-CRP), key secondary (ACR20), and exploratory endpo","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.globenewswire.com/news-release/2026/08/25/3350866/0/en/spyre-therapeutics-announces-topline-results-from-the-rheumatoid-arthritis-sub-study-of-the-skyway-phase-2-trial-of-spy072.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LENZ","RA","BK4539","BK4007","BK4139","SYRE","LFSC"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2660406265","title":"Is Spyre Therapeutics (SYRE) Fully Priced After Its SPY772 Program And SKYLIGHT Trial Launch?","url":"https://stock-news.laohu8.com/highlight/detail?id=2660406265","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2660406265?lang=en_us&edition=fundamental","pubTime":"2026-08-20 13:34","pubTimestamp":1787204046,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics stock reacts to new SPY772 program and SKYLIGHT trial launch\nSpyre Therapeutics (SYRE) is in focus after the company launched its SPY772 combination program and began SKYLIGHT, a Phase 2 proof of concept trial in Hidradenitis Suppurativa.\nBoth efforts target dual inhibition of TL1A and IL-17A/F in moderate to severe HS. The approach uses SPY072 alongside background bimekizumab therapy for around 150 adult participants.\nSee our latest analysis for Spyre Therapeutics.\nSpyre...","market":"us","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-syre/spyre-therapeutics/news/is-spyre-therapeutics-syre-fully-priced-after-its-spy772-pro","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-syre/spyre-therapeutics/news/is-spyre-therapeutics-syre-fully-priced-after-its-spy772-pro","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["LFSC","BK4139","SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2659173434","title":"LifeSci Capital Reaffirms Their Buy Rating on Spyre Therapeutics (SYRE)","url":"https://stock-news.laohu8.com/highlight/detail?id=2659173434","media":"TIPRANKS","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2659173434?lang=en_us&edition=fundamental","pubTime":"2026-08-15 22:35","pubTimestamp":1786804513,"startTime":"0","endTime":"0","summary":"In a report released today, Sam Slutsky from LifeSci Capital maintained a Buy rating on Spyre Therapeutics, with a price target of $129.00. Slutsky...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/lifesci-capital-reaffirms-their-buy-rating-on-spyre-therapeutics-syre-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/lifesci-capital-reaffirms-their-buy-rating-on-spyre-therapeutics-syre-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2659165757","title":"Analysts Offer Insights on Healthcare Companies: TransMedics Group (TMDX), Spyre Therapeutics (SYRE) and COMPASS Pathways (CMPS)","url":"https://stock-news.laohu8.com/highlight/detail?id=2659165757","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2659165757?lang=en_us&edition=fundamental","pubTime":"2026-08-13 23:40","pubTimestamp":1786635611,"startTime":"0","endTime":"0","summary":"Analysts have been eager to weigh in on the Healthcare sector with new ratings on TransMedics Group (TMDX), Spyre Therapeutics (SYRE) and COMPASS P...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-healthcare-companies-transmedics-group-tmdx-spyre-therapeutics-syre-and-compass-pathways-cmps-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-healthcare-companies-transmedics-group-tmdx-spyre-therapeutics-syre-and-compass-pathways-cmps-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4137","LU2324357040.USD","BK4082","BK4581","LU0029874061.USD","BK4585","LFSC","HCSG","LU0128526141.USD","BK4588","TMDX","CMPS","BK4139","SYRE","XBI","LABU","LU2065731478.USD","XLV","PSIL"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658916668","title":"Wedbush Keeps Their Buy Rating on Spyre Therapeutics (SYRE)","url":"https://stock-news.laohu8.com/highlight/detail?id=2658916668","media":"TIPRANKS","labels":["express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658916668?lang=en_us&edition=fundamental","pubTime":"2026-08-11 21:55","pubTimestamp":1786456528,"startTime":"0","endTime":"0","summary":"Wedbush analyst David Nierengarten maintained a Buy rating on Spyre Therapeutics today and set a price target of $130.00. 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