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SPYRE THERAPEUTICS INC

90.60

+1.892.13%

Post-market: 90.600.00000.00%19:30 EDT

Volume:886.06K

Turnover:79.81M

Market Cap:7.99B

PE:-45.08

High:91.41

Open:90.00

Low:87.89

Close:88.71

52wk High:110.18

52wk Low:14.51

Shares:88.17M

Float Shares:80.98M

Volume Ratio:0.88

T/O Rate:1.09%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.0100

EPS(LYR):-1.9755

ROE:-22.98%

ROA:-19.81%

PB:8.37

PE(LYR):-45.86

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Overview Company News Filings

Wall Street Analysts Are Bullish on Top Healthcare Picks

Spyre Therapeutics (SYRE) Receives a Rating Update from a Top Analyst

Analysts’ Top Healthcare Picks: Spyre Therapeutics (SYRE), BioCryst (BCRX)

Spyre Therapeutics' SPY003 Meets Phase 2 Primary Endpoint in Ulcerative Colitis

MT Newswires Live

Spyre Therapeutics announces 12-week induction data from Part A of SKYLINE trial

Spyre Reports Positive Phase 2 Skyline Part a Induction Data for UC Drug Spy003, Hits Primary Endpoint

Spyre Therapeutics - Spy003 Meets Primary Endpoint with 10.0-Point Rhi Reduction at Week 12

THOMSON REUTERS

Spyre Therapeutics - Spy003 Well Tolerated with Safety Profile Consistent with Il-23 Class

THOMSON REUTERS

Spyre Therapeutics - Spy003 Achieves 20% Clinical Remission and 30% Endoscopic Improvement at Week 12

THOMSON REUTERS

Spyre Therapeutics - Skyline Part B Enrolling; Topline Induction Data Expected in 2027

THOMSON REUTERS

Spyre Therapeutics Grants Inducement Awards of 2,106 Stock Options, 745 RSUs to New Employee

Spyre Therapeutics Announces Grants of Inducement Awards

Spyre Therapeutics CEO Turtle Cameron Disposes of 15,000 Common Shares Worth $1.31 Million

Analysts Offer Insights on Healthcare Companies: Revolution Medicines (RVMD) and Spyre Therapeutics (SYRE)

U.S. Research Roundup-CrowdStrike, Nvidia, Macerich

Top Midday Decliners

MT Newswires Live

Spyre Therapeutics falls -13.2%

Spyre Therapeutics Down over 12%, on Pace for Largest Percent Decrease Since June 2024

U.S. Stocks on the MOVE-Semtech, Donaldson, Meta

Spyre Therapeutics (SYRE) Gets a Buy from LifeSci Capital

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SKYLINE trial evaluating pairwise combinations now enrolling.Spyre expects topline SKYLINE part B induction data in 2027, with phase 2 SKYWAY results for SPY072 in psoriatic arthritis and axial spondyloarthritis expected in the fourth quarter of 2026, it added.Spyre Therapeutics shares were down 1.1% in premarket activity.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4539","BK4007","LENZ","SYRE","BK4139","LFSC"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665320733","title":"Spyre Therapeutics announces 12-week induction data from Part A of SKYLINE 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(NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company committed to developing next-generation t","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.globenewswire.com/news-release/2026/09/04/3356774/0/en/spyre-therapeutics-announces-grants-of-inducement-awards.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LENZ","LFSC","BK4139","BK4539","SYRE","BK4007"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2664388298","title":"Spyre Therapeutics CEO Turtle Cameron Disposes of 15,000 Common Shares Worth $1.31 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Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2662749365?lang=en_us&edition=fundamental","pubTime":"2026-08-27 02:23","pubTimestamp":1787768612,"startTime":"0","endTime":"0","summary":"Electromed  Chief Executive Jim Cunniff plans to retire around April 2 after serving as president and CEO since 2023, it said late Tuesday, adding that the board plans to search for his successor.Shares declined 18%, with intraday trading volume rising to over 229,000 from a daily average of about 89,000.Greenland Mines  shares slumped 43% amid heavy trading after the company said it priced its public offering of 4 million shares for gross proceeds of about $20 million.Intraday trading volume catapulted to over 2.09 million from a daily average of about 174,000.Spyre Therapeutics  said late Tuesday its experimental rheumatoid arthritis drug SPY072 failed to meet the company's internal performance threshold needed to justify further stand-alone development, prompting a halt of its monotherapy RA program.Shares dropped 14% as intraday trading volume rose to over 1.96 million from a daily average of about 1.25 million.Price: 32.20, Change: -7.14, Percent Change: -18.15","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["SYRE","BK4139","LFSC","GRML","BK4082","ELMD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2662474530","title":"Spyre Therapeutics falls 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Published first on TheFly – the ultimate source for real-time, market-moving breaki...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/spyre-therapeutics-falls-13-2-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/spyre-therapeutics-falls-13-2-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","LENZ","LFSC","SYRE","BK4139","BK4539"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2662104247","title":"Spyre Therapeutics Down over 12%, on Pace for Largest Percent Decrease Since June 2024","url":"https://stock-news.laohu8.com/highlight/detail?id=2662104247","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2662104247?lang=en_us&edition=fundamental","pubTime":"2026-08-26 22:35","pubTimestamp":1787754900,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics, Inc  is currently at $94.12, down $13.24 or 12.33%--Would be lowest close since July 16, 2026, when it closed at $94.12--On pace for largest percent decrease since June 17, 2024, when it fell 19.3%--Snaps a two day winning streak--Down 4.28% month-to-date; on pace for worst month since April 2025, when it fell 5.61%--Up 187.3% year-to-date--Down 68.6% from its all-time closing high of $299.75 on April 8, 2016--Up 449.12% from 52 weeks ago , when it closed at $17.14--Down 13.59% from its 52-week closing high of $108.92 on Aug. 19, 2026--Up 535.09% from its 52-week closing low of $14.82 on Sept. 16, 2025--Traded as low as $90.60; lowest 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